Summary
The fate of parenterally administered 32P-labeled liver phospholipids in tumor-bearing animals as well as in normal controlled animals was studied. The tumor was the only tissue which showed an increasing incorporation throughout the whole experiment.
Similarly, ascites cells revealed an in vitro uptake that increased as a function of the incubation time.
The comparison with the 32P uptake from 32P-orthoposphate indicates that the radioactivity incorporation in the phospholipid fraction is not due to de novo synthesis of phospholipid molecules. Tumor-bearing animals appear to have a faster excretion of injected 32P-phospholipids and a mobilization from other tissues to the tumor.
The incubation of the 32P-phospholipids with tissue homogenates shows effects on the various components of the phospholipids which are characteristic for each type of tumor.
Zusammenfassung
Es wurde sowohl an tumortragenden als auch an Hand von normalen Tieren das Verhalten von parenteral verabreichten, mit 32P markierten Leberphosphorlipoiden untersucht.
Der Tumor ist das einzige Gewebe, das eine zunehmende Inkorporation während des ganzen Experimentes zeigt.
Ähnlich zeigen Asziteszellen eine in vitro Aufnahme, die eine erhöhte Tätigkeit während der Inkubationszeit aufweist.
Der Vergleich zwischen der 32P Aufnahme aus 32P-orthophosphat zeigt an, daß die Registrierung der Radioaktivität in der phosphorlipoiden Fraktion nicht der de novo — Synthese von Phosphorlipoiden zugeordnet werden kann.
Es scheint, als hätten tumortragende Tiere eine schnellere Ausscheidung von injizierten 32P-Phosphorlipoiden und eine, durch den Tumor bedingte, Mobilisierung des anderen Gewebes.
Die Inkubation der 32P-Phosphorlipoide mit homogenisiertem Gewebe läßt verschiedene Zusammensetzungen der Phosphorlipoide erkennen, die für jeden Tumortyp charakteristisch sind.
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Diese Arbeit wurde mit der Unterstützung des Ministeriums für Wissenschaft u. Forschung des Landes Nordrhein-Westfalen durchgeführt.
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Anghileri, L.J. The uptake of phospholipids by experimental tumors. Z. Krebsforsch. 78, 326–336 (1972). https://doi.org/10.1007/BF00284346
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DOI: https://doi.org/10.1007/BF00284346