Summary
Five cyclic nitrosamines have been fed to groups of 30 MRC rats at a concentration of 100 mg/liter in drinking water. Nitroso-3-pyrroline produced only tumors of the liver, and was the weakest carcinogen of the five. Nitrosopiperidine induced tumors of liver, esophagus and respiratory tract. Nitrosomorpholine induced tumors of liver and the nasal cavity. Nitrosoheptamethyleneimine induced squamous tumors of lung, and tumors of the esophagus and trachea and was the most potent carcinogen of the five. Dinitrosopiperazine induced tumors of the nasal cavity. The reasons for the pronounced organ specificities of these nitrosamines are discussed.
Zusammenfassung
Gruppen von je 30 MRC-Ratten wurden in einer Konzentration von 100 mg/l im Trinkwasser Nitrosamine gegeben. Es entstanden nach Nitroso-3-pyrrolin, dem schwächsten Cancerogen, nur Lebertumoren, nach Nitrosopiperidin Tumoren von Leber, Speiseröhre und Respirationstrakt, nach Nitrosomorpholin Tumoren von Leber und Nasenhöhle, nach Nitrosoheptamethylenimin, dem stärksten Carcinogen, Plattenepitheltumoren der Lunge und Tumoren von Speiseröhre und Trachea, nach Dinitrosopiperazine Tumoren der Nasenhöhle. Die Gründe für die ausgesprochene Organspezifität dieser Nitrosoamine werden besprochen.
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Supported by Contract No. 43-68-959 from the National Cancer Institute, U. S. Public Health Service.
We wish to thank Mrs. J. Stroud for valuable technical assistance.
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Garcia, H., Lijinsky, W. Tumorigenicity of five cyclic nitrosamines in MRC rats. Z. Krebsforsch. 77, 257–261 (1972). https://doi.org/10.1007/BF00283967
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DOI: https://doi.org/10.1007/BF00283967