Summary
Cytogenetic studies were carried out on 150 oocytes obtained in a human in vitro fertilization (IVF) program. Although all cells lacked signs of fertilization at light microscopy, 46 (30.7%) appeared to show cytological evidence of fertilization. At least one-third of these cells (with development arrested before first cleavage) had chromosomal aberrations. An aneuploidy rate of 35% was found in unfertilized oocytes. The results of this study explain some of the fertilization failures and of the failures of postfertilization development.
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Pieters, M.H.E.C., Geraedts, J.P.M., Dumoulin, J.C.M. et al. Cytogenetic analysis of in vitro fertilization (IVF) failures. Hum Genet 81, 367–370 (1989). https://doi.org/10.1007/BF00283693
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DOI: https://doi.org/10.1007/BF00283693