Summary
Electrofocusing and agarose electrophoresis techniques both reveal polymorphism of ESD 2, which may be subdivided into two different proteins, coded for by genes allelic to ESD *1. After agarose electrophoresis, ESD 2 is slightly more anodally located than ESD 5, while the latter is considerably more acidic as revealed by electrofocusing in polyacrylamide gel slabs. Family studies have confirmed that each of the allele products behave as Mendelian characters: and the gene frequencies in a Norwegian population material are about 0.08 and 0.02 for the ESD *2 and ESD *5 alleles, respectively.
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Olaisen, B., Siverts, A., Jonassen, R. et al. The ESD polymorphism: Further studies of the ESD2 and ESD5 allele products. Hum Genet 57, 351–353 (1981). https://doi.org/10.1007/BF00281682
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DOI: https://doi.org/10.1007/BF00281682