Skip to main content
Log in

A new mathematical approach for solving carrier-facilitated steady-state diffusion problems

  • Published:
Journal of Mathematical Biology Aims and scope Submit manuscript

Summary

A new mathematical treatment is presented which simplifies the solution of carrier-diffusion problems. The method is generally applicable and is illustrated and tested for a specific, commonly occurring situation: facilitated diffusion of a single substrate through flat layers. Results predicted for total substrate flux are in excellent agreement with control computer calculations. The method also can be used to obtain concentration profiles for each species; here the results are good only if conditions at the boundaries are predicted correctly.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Gijsbers, G. H., van Ouwerkerk, H. J.: Boundary layer resistance of steady-state oxygen diffusion facilitated by a four-step chemical reaction with hemoglobin in solution. Pflügers Arch. 365, 231–241 (1976)

    Google Scholar 

  • Goddard, J. D., Schultz, J. S., Suchdeo, S. R.: Facilitated transport via carrier-mediated diffusion in membranes. II. Mathematical aspects and analyses. AIChE J. 20, 625–645 (1974)

    Google Scholar 

  • Hoofd, L., Kreuzer, F.: Calculation of the facilitation of O2 or CO transport by Hb or Mb by means of a new method for solving the carrier-diffusion problem, p. 163–168. In: Oxygen Transport to Tissue-III (Adv. Exper. Med. Biol., Vol. 94). New York and London: Plenum Press, 1978

    Google Scholar 

  • Kreuzer, F., Hoofd, L. J. C.: Facilitated diffusion of oxygen in the presence of hemoglobin. Respir. Physiol. 8, 280–302 (1970)

    Google Scholar 

  • Kreuzer, F., Hoofd, L. J. C.: Factors influencing facilitated diffusion of oxygen in the presence of hemoglobin and myoglobin. Respir. Physiol. 15, 104–124 (1972)

    Google Scholar 

  • Kreuzer, F., Hoofd, L. J. C.: Facilitated diffusion of CO and oxygen in the presence of hemoglobin or myoglobin, p. 207–215. In: Oxygen Transport to Tissue-II (Adv. Exper. Med. Biol., Vol. 75). New York and London: Plenum Press, 1976

    Google Scholar 

  • Mochizuki, M., Forster, R. E.: Diffusion of carbon monoxide through thin layers of hemoglobin solution. Science 138, 897–898 (1962)

    Google Scholar 

  • Scholander, P. F.: Oxygen transport through hemoglobin solutions. Science 131, 585–590 (1960)

    Google Scholar 

  • Schultz, J. S., Goddard, J. D., Suchdeo, S. R.: Facilitated transport via carrier-mediated diffusion in membranes. I. Mechanistic aspects, experimental systems and characteristic regimes. AIChE J. 20, 417–445 (1974)

    Google Scholar 

  • Smith, K. A., Meldon, J. H., Colton, C. K.: An analysis of carrier-facilitated transport. AIChE J. 19, 102–111 (1973)

    Google Scholar 

  • Ward, W. J.: Analytical and experimental studies of facilitated transport. AIChE J. 16, 405–410 (1970)

    Google Scholar 

  • Wittenberg, J. B.: The molecular mechanism of hemoglobin-facilitated oxygen diffusion. J. Biol. Chem. 241, 104–111 (1966)

    Google Scholar 

  • Yung, D., Probstein, R. F.: Similarity considerations in facilitated transport. J. Phys. Chem. 77, 2201–2205 (1973)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoofd, L., Kreuzer, F. A new mathematical approach for solving carrier-facilitated steady-state diffusion problems. J. Math. Biology 8, 1–13 (1979). https://doi.org/10.1007/BF00280581

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00280581

Key words

Navigation