Summary
In a double-blind cross-over study, 12 patients with reversible airways obstruction were treated with 200 μg salbutamol base in aerosol or 400 μg of powder following methacholine-induced bronchoconstriction. Salbutamol was inhaled either from a conventional metered dose inhaler (MDI) or from an inhaler (Diskhaler®) utilizing the powdered form of the drug.
The efficacy of both forms was identical whether assessed in terms of FEV1 or vital capacity. The ratio of the increase in FEV1 or vital capacity after bronchodilatation to the decrease during the prior bronchoconstriction was 1.4, indicating that both FEV1 and vital capacity improved over baseline following bronchodilatation. In six subjects, the onset of action of the powder form was more rapid, and in four the MDI acted more rapidly. In the group as a whole, the mean time constant for the action of salbutamol was identical (3.8 min) for the two forms.
It is concluded that salbutamol powder has a similar efficacy and time course of action as the aerosol, probably because both formulations produce similar sized particles of the drug.
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References
De Blaquoere P, Christensen DB, Carter WB, Martin T (1989) Use and misuse of metered-dose inhaler by patients with chronic lung disease. Am Rev Respir Dis 140: 910–916
Mathieu M, Sartene R (1987) Evaluation of the end-expiratory lung volume as an indirect index of bronchial constriction in asthma. Bull Eur Physiopathol Respir 23: 429–434
American Thoracic Society (1962) Definition and Classification of Chronic Bronchitis, Asthma, and Pulmonary Emphysema. Am Rev Respir 84: 762–768
European Coal and Steel Community (1983) Standardization of lung function test. Bull Eur Physiopathol Respir 19 [Suppl 15]: 7–10
Sartene R, Martinot Lagarde P, Mathieu M, Vincent A, Goldman M, Durand G (1990) Respiratory cross-sectional area flux measurements of the human chest wall. J Appl Physiol 68: 1605–1610
Gayrard P, Orehek J, Grimaud CN, Charpin J (1975) Bronchoconstrictor effects of a deep inspiration in patients with asthma. Am Rev Respir 111: 433–439
Popa V, Chandnani PC; Reardon M (1990) The Relationship Between Conductance and Functional Residual Capacity during Drug-Induced Bronchoconstriction. Chest 97: 831–839
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Mathieu, M., Goldman, M., Lellouche, N. et al. Kinetics of action of salbutamol inhaled from a metered dose inhaler (MDI) and a “diskhaler”. Eur J Clin Pharmacol 42, 435–438 (1992). https://doi.org/10.1007/BF00280131
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DOI: https://doi.org/10.1007/BF00280131