Summary
46Sc-and 99mTc-labelled microspheres were used to measure the effects of noradrenaline infusion on cardiac output and its regional distribution in 10 control and 10 streptozotocin-diabetic pithed rats. Plasma noradrenaline concentrations during the infusion were similar in both groups. Pressor responses were significantly smaller in the diabetic animals (controls: + 79, diabetic: +44mmHg; p<0.001). Cardiac output remained similar in both groups before and during the noradrenaline infusion. Total peripheral resistance was similar in both groups before noradrenaline but the noradrenaline-mediated increase was significantly smaller in the diabetic animals (controls: +150%, diabetic: + 76%; p<0.05). Noradrenaline-mediated resistance increases were significantly reduced in several tissues of the diabetic rats including the small intestine (controls: + 132%, diabetic: −4%; p<0.005), the large intestine (controls: +150%, diabetic: +39%; p<0.05) and the kidneys (controls: +180%, diabetic: + 27%;p<0.05), but were very similar in other areas, e.g. in the hindlimbs and tails.
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Lucas, P.D. Effects of streptozotocin-induced diabetes and noradrenaline infusion on cardiac output and its regional distribution in pithed rats. Diabetologia 28, 108–112 (1985). https://doi.org/10.1007/BF00279926
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DOI: https://doi.org/10.1007/BF00279926