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Variable substructure in the secondary constriction of the human chromosome 1

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Summary

The secondary constriction in human chromosome 1 consists of a proximal segment stained by the GC-specific fluorochrome mithramycin and a distal segment stained by such fluorochromes as DAPI or DIPI, which show enhanced fluorescence intensities in AT-rich regions of the chromosomes. A study involving 21 individuals revealed that both parts are independently involved in length variability. In two cases, two GC-rich regions separated by an AT-rich segment and an additional distal AT-rich part were found.

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Authors and Affiliations

  1. Histologisch-Embryologisches Institut der Universität Wien, Schwarzspanierstraße 17, A-1090, Wien, Austria

    J. Sigmund & S. Schwarz

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  1. J. Sigmund
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  2. S. Schwarz
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Sigmund, J., Schwarz, S. Variable substructure in the secondary constriction of the human chromosome 1. Hum Genet 46, 1–4 (1979). https://doi.org/10.1007/BF00278895

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  • DOI: https://doi.org/10.1007/BF00278895

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