Summary
We have demonstrated in a group of 10 patients with CAO that treatment with xamoterol (200 mg b.i.d. for 7 days) did not alter lung function or respiratory symptoms.
These results suggest that xamoterol can be used to treat mild heart failure in patients with CAO.
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References
Wood C, Rue Y (1982) Heart failure in the community. R Soc Med Forum no. 6
The German and Austrian xamoterol study group (1988) Double blind placebo controlled comparison of digoxin and xamoterol in chronic heart failure. Lancet I: 489–493
Waller DG, Webster J, Sykes CA, Bhalla KK (1989) Clinical effects of xamoterol, a β1-adrenoceptor partial agonist in mild to moderate heart failure. Eur Heart J 11: 1003–1100
Nuttall A, Snow HM (1982) The cardiovascular effects of ICI 118,857; a beta-adrenoceptor partial agonist. Br J Pharmacol 77: 281–285
Lofdahl CG, Svedmyr N (1984) Effects of xamoterol in asthmatic patients. Br J Clin Pharmacol 18: 597–601
Lammers JWJ, Muller METM, Folgering HTHM, van Herwaarden CLA (1986) A comparative study on the ventilatory and haemodynamic effects of xamoterol and atenolol on asthmatic patients. Br J Clin Pharmacol 22: 595–602
Wunderlich J, Macha HN, Wudiche H, Huckauf H (1980) Beta-adrenoceptor blockers and Terbutaline in patients with chronic obstructive lung disease. Chest 78: 714–720
Chester EH, Schwartz HJ, Fleming GM (1981) Adverse effect of Propranolol on airway function in nonasthmatic chronic obstructive lung disease. Chest 79: 540–544
Lewis RP, Rittgere SE, Forester WF, Barrdonlas H (1977) A critical review of systolic time intervals. Circulation 56: 146–158
Marlow HF (1989) Dose-response relationships of xamoterol. Eur J Clin Pharmacol 36 [Suppl] 06–64 abstract
Roberts JA, Pugh JR, Thomson NC (1986) A new adaptable computerised system for the measurement of specific airways conduction. Br J Dis Chest 80: 218–228
DuBois AB, Botelho SY, Comroe JH Jr (1956) A new method for measuring airways resistance in man using a body plethysmograph: values in normal subjects and patients with respiratory disease. J Clin Invest 35: 327–335
Meurs H, Dirkle SM, Koeter GH, Keyser JJ, Timmermans A, Kauffman HF, deVries K (1987) The Beta-adrenoceptor system of non allergic patients with chronic airflow obstruction and early morning dyspnoea. Ann Allergy 59: 417–421
Barnes PJ, Pride NB (1983) Dose-response curves to inhaled B-adrenoceptor agonists in normal and asthmatic subjects. Br J Clin Pharmacol 15: 677–682
Foresti A, Chetta A, Corbo GM, Cuomo A, Oliveri D (1987) Provocative dose and dose-response curve to inhaled propranolol in asthmatic patients with bronchial hyperresponsiveness to methacholine. Chest 92: 455–459
Ind PW, Dixon CMS, Fuller RW, Barnes PJ (1989) Anticholinergic blockade of Beta-blocker induced bronchoconstriction. Am Rev Respir Dis 139: 1390–1394
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Roberts, J.A., Challenor, V.F. & Waller, D.G. Is xamoterol safe in chronic airflow obstruction?. Eur J Clin Pharmacol 42, 147–150 (1992). https://doi.org/10.1007/BF00278474
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DOI: https://doi.org/10.1007/BF00278474