Summary
Linkage data of the four gene markers Pi, Gm, GLO, and HLA exclude Gm and Pi gene assignment to the short arm of chromosome 6. The findings, however, do not disprove the following gene order: HLA-GLO-centromere-Gm-Pi.
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Bodmer, W. F.: Report of the Committee on the Genetic Constitution of Chromosome 6. Baltimore Conference (1975). Third International Workshop on Human Gene Mapping. Birth Defects: Original Article Series XII: 7, 24–30. New York: The National Foundation, 1976
Borgaonkar, D. S., Bias, W. B., Chase, G. A., Sadasivan, G., Herr, H. M., Golomb, H. M., Bahr, G. F., Kunkel, L. M.: Identification of a C6/G21 translocation chromosome by the Q-M and Giemsa banding techniques in a patient with Down's syndrome, with possible assignment of Gm locus. Clin. Genet. 4, 53–57 (1973)
Breuning, M. H., Van Den Berg-Loonen, E. M., Bernini, L. F., Bijlsma, J. B., Van Loghem, E., Meera-Khan, P., Nijenhuis, L. E.: Localization of HLA on the short arm of chromosome 6. Hum. Genet. 37, 131–139 (1977)
Francke, U., Pellegrino, M. A.: Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6. Proc. Natl. Acad. Sci. USA 74, 1147–1151 (1977)
Gedde-Dahl, T. Jr., Fagerhol, M. K., Cook, P. J. L., Noades, J. E.: Autosomal linkage between the Gm and Pi loci in man. Ann. Hum. Genet. 35, 393–399 (1972)
Gedde-Dahl, T. Jr., Cook, P. J. L., Fagerhol, M. K., Pierce, J. A.: Improved estimate of the Gm-Pi linkage. Ann. Hum. Genet. 39, 43–50 (1975)
Genz, T., Martin, J.-P., Cleve, H.: Classification of a 1-antitrypsin (Pi) phenotypes by iso-electrofocusing. Distinction of six subtypes of the Pi M phenotype. Hum. Genet. 38, 325–332 (1977)
Grzeschik, K. H., Mayerová, A., Bender, K., Johannsmann, R.: Regional submapping of human chromosome 6 by the use of human-mouse somatic cell hybrids. Human Gene Mapping 4 (in press, 1979)
Kissmeyer-Nielsen, F., Kjerbye, K. E.: Lymphocytotoxic microtechnique. Purification of lymphocytes by flotation. In: Histocompatibility testing 1967, pp. 381–383. Kopenhagen: Munksgaard 1967
Lamm, L. U., Thorsen, I.-L., Petersen, G. B., Jørgensen, J., Henningsen, K., Bech, B., Kissmeyer-Nielsen, F.: Data on the HL-A linkage group. Ann. Hum. Genet. 38, 383–390 (1975)
Maynard-Smith, S., Penrose, L. S., Smith, C. A. B.: Mathematical tables for research workers in human genetics. London: Churchill 1961
Mayr, W. R., Mayr, D.: Analyse der Kopplung zwischen dem HLA-System und anderen Loci. Humangenetik 24, 129–133 (1974)
Mayr, W. R., Mayr, D., Kömpf, J., Bissbort, S., Ritter, H.: Possible linkage of HLA and GLO. Hum. Genet. 31, 241–242 (1976)
Noades, J. E., Cook, P. J. L.: Family studies with the Gm: Pi linkage group. Baltimore Conference (1975). Third International Workshop on Human Gene Mapping. Birth Defects: Original Article Series XII: 7, 341–344. New York: The National Foundation, 1976
Noades, J. E., Ball, M. J., McCloghry, F. J.: An investigation of a proposed linkage between Rhesus and Gm systems. Blut 37, 27–29 (1978)
Smith, M., Hirschhorn, K.: Location of the genes for human heavy chain immunoglobulin to chromosome 6. Proc. Natl. Acad. Sci. USA 75, 3367–3371 (1978)
Weitkamp, L. R., May, A. G., Johnston, E.: The linkage relationships of HL-A with other genetic marker systems. Hum. Hered. 25, 337–345 (1975)
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Bender, K., Müller, C.R., Schmidt, A. et al. Linkage studies on the human Pi, Gm, GLO, and HLA genes. Hum Genet 49, 159–166 (1979). https://doi.org/10.1007/BF00277637
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DOI: https://doi.org/10.1007/BF00277637