Abstract
The correlation between manganese deficiency, loss of mitochondrial respiratory chain NADH: ubiquinone oxidoreductase (complex I) activity and citric acid overproduction in the Aspergillus niger strain B 60 was analysed. With increasing manganese-supplementation of the production medium the loss of complex I activity and the production of citric acid was reduced. Addition of manganese during growth stopped further loss of complex I activity and further increase of citric acid production. A possible causality between complex I deficiency and citric acid overproduction is discussed.
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Wallrath, J., Schmidt, M. & Weiss, H. Correlation between manganese-deficiency, loss of respiratory chain complex I activity and citric acid production in Aspergillus niger . Arch. Microbiol. 158, 435–438 (1992). https://doi.org/10.1007/BF00276305
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DOI: https://doi.org/10.1007/BF00276305