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Incidence of chromosomal rearrangements in couples with reproductive loss

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Summary

We report on 50 couples with reproductive loss who did not have any detectable chromosome abnormality. A history of a previous child with multiple congenital abnormalities may be significant in identifying couples with a structural rearrangement. Only by studying more families can this hypothesis be tested. Studies of abortus tissue reveal a high percentage of chromosome abnormalities but a very low incidence of unbalanced translocations. Cytogenetic studies are indicated in a couple which has a past history of spontaneous abortions and a previous child with multiple congenital anomalies.

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Authors and Affiliations

  1. Department of Pediatrics, North Shore University Hospital, 300 Community Drive, 11030, Manhasset, NY, USA

    Nataline B. Kardon, Jessica G. Davis, Ann L. Berger & Afina Broekman

  2. Department of Pediatrics, Cornell University Medical College, New York, NY, USA

    Nataline B. Kardon, Jessica G. Davis, Ann L. Berger & Afina Broekman

Authors
  1. Nataline B. Kardon
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  2. Jessica G. Davis
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  3. Ann L. Berger
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  4. Afina Broekman
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Kardon, N.B., Davis, J.G., Berger, A.L. et al. Incidence of chromosomal rearrangements in couples with reproductive loss. Hum Genet 53, 161–164 (1980). https://doi.org/10.1007/BF00273488

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  • DOI: https://doi.org/10.1007/BF00273488

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