Summary
A dominant suppressor has been discovered which suppresses polarity type mutations, noncomplementing ones and those belonging to short nonpolar complementation groups at the ad 2 locus of S. cerevisiae. The suppressor translates two types of nonsense previously established at ad 2. These data together with theoretical consideration of relationships between nonsense-translating anticodons and different codons make it possible to suggest a mechanism for the observed suppression. According to this mechanism two nonsense types of ad 2 are identified as amber and ochre codons.
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Communicated by D. Goldfarb
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Simarov, B.V., Mironova, L.N. & Inge-Vechtomov, S.G. Nonsense-missense suppression in yeast. Molec. Gen. Genet. 113, 302–307 (1971). https://doi.org/10.1007/BF00272330
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DOI: https://doi.org/10.1007/BF00272330