Summary
HLA A and B antigens have been determined in 2740 adult responders to a population health survey in Busselton, Western Australia. HLA A B and C antigens have been determined in 481 schoolchildren. The antigen frequencies are generally close to those obtained elsewhere for subjects of British origin, but there are some differences from the frequencies found in North American Caucasians. The frequencies were not affected by the inclusion of genetically related individuals in the sample. Seventeen HLA A-B haplotypes, six A-C haplotypes and six B-C haplotypes had frequencies above 1%. A total of 1071 distinct phenotypes were identified out of the 5069 which are theoretically possible for the HLAA-B model used in the study. The most frequent phenotype was A2, B12 which occurred in 2.5% of the sample.
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References
Bodmer, J.: The ABC of HLA. In: Histocompatibility testing 1975, F. Kissmeyer-Nielsen, ed., pp. 21–29. Copenhagen: Munksgaard 1975
Ceppellini, R., Curtoni, E. S., Mattiuz, P. L., Miggiano, V., Scudeller, G., Serra, A.: Genetics of leukocyte antigens: A family study of segregation and linkage. In: Histocompatibility testing 1967, E. S. Curtoni, P. L. Mattiuz, R. M. Tosi, eds., pp 149–185. Copenhagen: Munksgaard 1967
Cross, R., Tait, B.: Recommendations for a standard tissue typing technique for the detection of serologically defined antigens. In: The Australasian Tissue-typing Workshop 1977, R. L. Dawkins, J. D. Wetherall, eds., p. 133. Perth: University of Western Australia 1977
Curnow, D. H., Cullen, K. J., McCall, M. G., Stenhouse, N. S., Welborn, T. A.: Health and disease in a rural community. A Western Australian study. Aust. J. Sci. 31, 281–285 (1969)
Hawkins, B. R., Wetherall, J. D., Jones, A. L., Dawkins, R. L.: Distribution of HLA antigens in the Busselton population. In: The Australasian Tissue-typing Workshop, R. L. Dawkins, J. D. Wetherall, eds., pp. 100–104. Perth: University of Western Australia 1977
Högman, C. F., Lindblom, J. B.: The probability of donor-recipient histocompatibility in different HL-A phenotype combinations. Tissue Antigens 1, 197–208 (1971)
Mayr, W. R.: HLA-A, B, C gene and haplotype frequencies in Vienna. An analysis of family data. Hum. Genet. 37, 41–48 (1977)
Svejgaard, A., Hauge, M., Kissmeyer-Nielsen, F., Thorsby, E.: HLA haplotype frequencies in Denmark and Norway. Tissue Antigens 1, 184–195 (1971)
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Hawkins, B.R., Houliston, J.B. & Dawkins, R.L. Distribution of HLA A, B and C antigens in an Australian population. Hum Genet 52, 193–201 (1979). https://doi.org/10.1007/BF00271573
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DOI: https://doi.org/10.1007/BF00271573