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DNA repair in E. coli strains deficient in single-strand DNA binding protein

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Summary

Weigle reactivation and mutagenesis have been found to be defective in strains of E. coli deficient in single-strand DNA binding protein (SSB). These defects parallel those previously found in prophage induction and amplification of recA protein synthesis in ssb strains. Together, these results demonstrate a role for SSB in the induction of SOS responses. UV survival studies of ssb - recA- and ssb - uvr- strains are presented which also suggest a role for SSB in recombinational repair processes but not in excision repair. Studies of host cell reactivation support this latter conclusion.

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Authors and Affiliations

  1. Department of Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA

    Robert F. Whittier & John W. Chase

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  1. Robert F. Whittier
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  2. John W. Chase
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Communicated by B.A. Bridges

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Whittier, R.F., Chase, J.W. DNA repair in E. coli strains deficient in single-strand DNA binding protein. Molec. Gen. Genet. 183, 341–347 (1981). https://doi.org/10.1007/BF00270638

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  • DOI: https://doi.org/10.1007/BF00270638

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