Summary
Body-weight has been shown to influence the final expression of genetic damage by X-rays in Drosophila melanogaster. If larvae of Drosophila were raised up to the third instar in media containing different amounts of the same nutrient and in different conditions of crowding a positive correlation was observed between body-weight and frequency of chromosome aberrations induced by a given dose of X-rays in the somatic cells of their nerve ganglia. This effect, present in both sexes, is most plausibly attributed to a different capacity of big and small larvae for repairing radiation damage.
Similar content being viewed by others
References
Auerbach, Ch., Moser, H.: An analysis of the mutagenic action of formaldehyde food. Io Sensitivity of Drosophila germ cells. Z. indukt. Abstamm.-u. Vererbungsl. 85, 479–504 (1953)
Bajerska, A., Liniecki, J.: The influence of temperature at irradiaton in vitro on the yield of chromosomal aberrations in peripheral blood lymphocytes. Int. J. Radiat. Biol. 16, 213–232 (1953)
Clark, A.M.: Influence of the nutritional state of females on the frequency of X/O males recovered after matings with irradiated males. DIS 49, 75 (1972)
Conger, A.D.: The effect of oxygen on the radiosensitivity of mammalian cells. Radiology 66, 63–69 (1956)
De Marco, A.: Body-weight and crossing-over in Drosophila melanogaster. Atti AGI 1976 (in press)
Evans, H.J.: Repair and recovery from chromosome damage after fractionated X-rays dosage. In: Genetical aspects of radiosensitivity: Mechanism of repair, pp. 31–48. Vienna: Inter. Atomic Energy Agency 1966
Evans, H.J.: Repair and recovery from chromosome damage induced by fractionated X-ray exposures. In: Radiation research, pp. 482–501. Amsterdam: North Holland Publ. Comp. 1967
Gatti, M., Pimpinelli, S., De Marco, A., Tanzarella, C.: Chemical induction of chromosome aberrations in somatic cells of Drosophila melanogaster. Mutation Res. 33, 201–212 (1975)
Gatti, M., Tanzarella, C., Olivieri, G.: Analysis of the chromosome aberrations induced by X-rays in somatic cells of Drosophila melanogaster. Genetics 77, 701–719 (1974)
Herskowitz, I.H.: An influence of maternal nutrition upon the gross chromosomal mutation frequency recovered from X-rayed sperm of Drosophila melanogaster. Genetics 48, 703–710 (1963)
Proust, J.P., Sankaranarayanan, K., Sobels, F.: The effect of treating Drosophila females with actynomycin-D on the yields of dominant lethals, translocations and recessive lethals recovered from X-irradiated spermatozoa. Mutation Res. 16, 65–76 (1972)
Revell, S.H.: Chromosome breakage by X-rays and radiomimetic substances in Vicia. Heredity (Suppl.) 6, 107–124 (1953)
Sax, K., Enzman, B.V.: The effect of temperature of X-ray induced chromosome aberrations. Proc. nat. Acad. Sci. (Whas.) 25, 397–405 (1939)
Thoday, J.M., Read, J.: Effect of oxygen on the frequency of chromosome aberrations produced by X-rays. Nature (Lond.) 160, 608 (1947)
Watson, G.E., Gillies, N.E.: The oxygen enhancement ratio for X-ray induced chromosomal aberrations in cultured human lymphocytes. Int. J. Radiat. Biol. 17, 279–283 (1970)
Whitehouse, H.L.K.: Towards an understanding of the mechanism of heredity. London: Edward Arnold 1965
Zeiger, E.: Dietary effects on the mutagenicity of N-nitroso compounds in the host-mediated assay. Abstr. Ist. Int. Conf. on Environm. Mutagens, Asilomar 15 (1973)
Author information
Authors and Affiliations
Additional information
Communicated by Ch. Auerbach
Rights and permissions
About this article
Cite this article
De Marco, A., Belloni, M.P. Body-weight and chromosome aberrations induced by X-rays in somatic cells of Drosophila melanogaster . Molec. Gen. Genet. 146, 1–4 (1976). https://doi.org/10.1007/BF00267976
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00267976