Abstract
We report on five children (three female and two male, age span 11–16 years) with laboratory-supported definite multiple sclerosis, or clinically definite multiple sclerosis, diagnosed on the basis of Poser and Paty criteria. All patients were subjected to serial clinical examinations, magnetic resonance investigations, CSF biochemical and immunological studies, and neurophysiological and neuropsychological assessments. Four of the five examined subjects underwent steroid treatment. Over a period of 3 years relapses have been observed in three of them. The first symptoms and signs of multiple sclerosis may be subtle and misleading; careful assessment of them may be crucial for an early diagnosis of the disease.
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Refereces
Afifi KA, Bell WE, Menezes AH, Moore SA (1994) Myelinoclastic diffuse sclerosis (Schilder's disease): report of a case and review of the literature. J Child Neurol 9:398–403
Beck RW, Cleary PA, Trobe JD, Kaufman DI, Kupersmith MJ, Paty DW, Brown CH, and the Optic Neuritis Study Group (1993) The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. N Engl J Med 329:1764–1769
Boutin B, Esquivel E, Mayer M, Chaumet S, Ponsot G, Arthuis M (1988) Multiple sclerosis in children: report of clinical and paraclinical features of 19 cases. Neuropediatrics 19:118–123
Caltagirone C, Gainotti G, Masullo C, Miceli G (1979) Validity of some neuropsychological tests in the assessment of mental deterioration. Acta Psychiatr Scand 60:50–56
Duquette P, Murray TJ, Pleines J, Ebers GC, Sadovnik D, Weldon P, Warren S, Paty DW, Upton A, Hader W, Nelson R, Auty A, Neufeld B, Meltzer C (1987) Multiple sclerosis in childhood: clinical profile in 125 patients. J Pediatr 111:359–363
Frederiksen JL, Larsson HBW, Olesen J (1992) Correlation of magnetic resonance imaging and CSF findings in patients with acute monosymptomatic optic neuritis. Acta Neurol Scand 86:317–322
Goodin DS (1991) The use of immunosuppressive agents in the treatment of multiple sclerosis: a critical review. Neurology 41:980–985
Guihoto LMFF, Osorio CAM, Machado LR, Pereira de Castro C, Manrezza MLG, Callegaro D, Kok F, Diament A (1995) Pediatric multiple sclerosis report of 14 cases. Brain Dev 17:9–12
Hanefeld F, Bauer HJ, Christen HJ, Kruse B, Bruhn H, Frahm J (1991) Multiple sclerosis in childhood: report of 15 cases. Brain Dev 13:410–416
Hanefeld FA (1995) Characteristics of childhood multiple sclerosis. Int MS J 1:91–97
Kepes JJ (1993) Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients. Ann Neurol 33:18–27
Kriss A, Francis DA, Cuendet F, Halliday AM, Taylor DSI, Wilson J, Keast-Butler J, Batchelor JR, McDonalds WI (1988) Recovery after optic neuritis in childhood. J Neurol Neurosurg Psychiatry 51:1253–1258
Kurtzke JF (1994) Clinical definition for multiple sclerosis treatment trials. Ann Neurol 36:S73-S79
Maeda Y, Kitamoto I, Kurokawa T, Ueda K, Hasuo K, Fujioka K (1989) Infantile multiple sclerosis with extensive white matter lesions. Pediatr Neurol 5:317–319
Paty DW (1992) Magnetic resonance imaging in the diagnosis and followup of patients with multiple sclerosis. Ital J Neurol Sci [Suppl] 2:125–131
Paty DW (1993) Magnetic resonance in multiple sclerosis. Curr Opin Neurol Neurosurg 6:202–208
Paty DW, Oger JJF, Kastrukoff LF, Hashimoto SA, Hooge JP, Eisen AA, Eisen KA, Purves SJ, Low MD, Brandejs V, Robertson WD, Li DKB (1988) MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding and CT. Neurology 38:180–184
Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231
Pzzilli C, Gasperini C, Anzini A, Grasso MG, Ristori G, Fieschi C (1993) Anatomical and functional correlates of cognitive deficit in multiple sclerosis. J Neurol Sci 115 [Suppl]: S55-S58
Riikonen R, Ketonen L, Sipponen J (1988) Magnetic resonance imaging, evoked responses and cerebrospinal fluid findings in a follow-up study of children with optic neuritis. Acta Neurol Scand 77:44–49
Riikonen R, Donner M, Erkkila H (1988) Optic neuritis in children and its relationship to multiple sclerosis: a clinical study of 21 children. Dev Med Child Neurol 30:349–359
Sindern E, Haas J, Stark E, Wurster U (1992) Early onset MS under the age of 16: clinical and paraclinical features. Acta Neurol Scand 86:280–284
Sipe JC, Romine JS, Koziol JA, McMillan R, Zyroff J, Beutler E (1994) Cladribine in treatment of chronic progressive multiple sclerosis. Lancet 344:9–13
The IFNB Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double blind, placebo-controlled trial. Neurology 43:655–661
Van Lieshout HBM, Van Engelen BGM, Sanders EACM, Renier WO (1993) Diagnosing multiple sclerosis in childhood. Acta Neurol Scand 88: 339–343
Wakai S, Watanabe Y, Ichiki T, Watanabe T, Numata K, Tachi N, Matsumoto H, Chiba S (1994) Childhood multiple sclerosis: MR images and clinical variations in four Japanese cases. Brain Dev 16:52–56
Wolfson C, Wolfson DB (1993) The latent period of multiple sclerosis: a critical review. Epidemiology 4:464–470
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Iannetti, P., Spalice, A., Raucci, U. et al. Primary CNS demyelinating diseases in childhood: multiple sclerosis. Child's Nerv Syst 12, 149–154 (1996). https://doi.org/10.1007/BF00266819
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DOI: https://doi.org/10.1007/BF00266819