Summary
Therad 3 gene ofSaccharomyces cerevisiae appears to code for one of the enzymes involved in the repair of UV induced pyrimidine dimers. Haploid and diploid yeast cultures carrying different mutant alleles of therad 3 gene show considerable variation in their responses to both UV inactivation and post UV modifying treatments such as liquid holding in basal medium and photoreactivation. Positive liquid holding recovery was shown only by those diploid cultures containing alleles which conferred the highest levels of UV resistance. The results indicate that liquid holding recovery in yeast requires the activity of the excision-repair pathway for expression.
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Communicated by F. Kaudewitz
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Waters, R., Parry, J.M. A comparative study of the effects of UV irradiation upon diploid cultures of yeast defective at therad 3 locus. Molec. Gen. Genet. 124, 145–156 (1973). https://doi.org/10.1007/BF00265147
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DOI: https://doi.org/10.1007/BF00265147