Abstract
The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329±117 nmol·g−1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the blood, brain, fat, kidney, liver and muscle. The extent of conjugation of 2,4,6-trichlorophenol was also investigated by measuring total and free chlorophenol in the blood.
Similar content being viewed by others
References
Ahlborg UG, Larsson K (1978) Metabolism of tetrachlorophenols in the rat. Arch Toxicol 40: 63–74
Aitio A, Vainio H (1976) UDPGIucuronyltransferase and mixed function oxidation in microsomes prepared by differential centrifugation and calcium aggregation. Acta Pharmacol Toxicol 39: 555–561
Brown WH, Young JD, Blau GE, Gehring PJ (1977) The pharmacokinetics and metabolism of pentachlorophenol in rats. Toxicol Appl Pharmacol 41: 395–406
Dutton GL (1968) Glucuronic acid, free and combined. Academic Press, New York
IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans (1979) 2,4,5- and 2,4,6-trichlorophenols, Lyon, 20: 349–367
Kalman DA, Horstman SV (1983) Persistence of tetrachlorophenol and pentachlorophenol in exposed workers. J Toxicol — Clin Toxicol 20: 343–352
Larsen RV, Kirch LE, Shaw SM, Christian JE, Born GS (1972) Excretion and tissue distribution of uniformly labelled 14C-pentachlorophenols in the rats. J Pharm Sci 61: 2004–2006
Needham LL, Cline RE, Head SL, Liddle JA (1981) Determining pentachlorophenol in body fluids by gas chromatography after acetylation. J Anal Toxicol 5: 283–286
Pekari K, Aitio A (1982) A simple liquid Chromatographic method for the analysis of penta- and tetrachlorophenols in urine of exposed workers. J Chromatogr 232: 129–136
Pekari K, Järvisalo J, Aitio A (1985) Kinetis of urinary excretion of 2,4,6-tri-, 2,3,4,6-tetra- and pentachlorophenol in workers exposed in lumber treatment. 26th Congress of the European Society of Toxicology, Abstracts, June 16–19, University of Kuopio, Finland
Savolainen H, Pekari K (1979) Neurochemical effects of peroral administration of technical pentachlorophenol. Res Commun Chem Pathol Pharmacol 23: 97–105
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pekari, K., Boudène, C. & Aitio, A. Kinetics of 2,4,6-trichlorophenol in different organs of the rat. Arch Toxicol 59, 41–44 (1986). https://doi.org/10.1007/BF00263956
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00263956