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Renal hypercalciuria and metabolic acidosis associated with medullary sponge kidney: Effect of alkali therapy

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Summary

Sixteen patients with medullary sponge kidney (MSK) and renal stones underwent evaluation of calcium metabolism and acid base balance. Six normal subjects and eight patients with non-MSK absorptive hypercalciuria served as control. Nine (56%) were hypercalciuric and seven (44%) were normocalciuric (N-MSK). Hypercalciuria was divided into absorptive (AH-MSK, n=2) and renal leak hyerpcalciuria (RH-MSK, n=7). The mean of minimal urine pH of RH-MSK group (5.28±0.09 (SE)) was significantly higher than that of normal control (4.78±0.12) and of non-MSK AH (4.80±0.6) during acute acid challenge. The mean of the arterial blood HCO3 concentration of RH-MSK group was significantly lower than that of two control groups. The urine calcium and a frequency of stone passage were decreased significantly after alkali treatment in RH-MSK.

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    E. Higashihara, K. Nutahara & T. Niijima

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  1. E. Higashihara
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  2. K. Nutahara
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  3. T. Niijima
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This investigation was supported in part by a grant from the Japanese Educational Ministry

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Higashihara, E., Nutahara, K. & Niijima, T. Renal hypercalciuria and metabolic acidosis associated with medullary sponge kidney: Effect of alkali therapy. Urol. Res. 16, 95–100 (1988). https://doi.org/10.1007/BF00261964

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  • DOI: https://doi.org/10.1007/BF00261964

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