Skip to main content
SpringerLink
Log in

Einfluß der Substanz P auf die elektrische Aktivität des Gehirns

  • Published:
Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie Aims and scope Submit manuscript

Summary

The EEG of the cortex and the hippocampus has been recorded in rabbits after injection of substance P into the carotis artery. 30 to 100 units of substance P evoced the following effects:

  1. 1.

    The cortical activity showed a decrease in amplitude and an increase in frequency, most pronounced 1–2 min after the injection.

  2. 2.

    The hippocampus activity showed an increase in frequency synchronisation of the previously irregular basic pattern. These changes of electrical activity suggest an influence of substance P on activatingsystems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Amin, A. H., T. B. B. Crawford and J. H. Gaddum: J. Physiol. (Lond.) 126, 596 (1954).

    Google Scholar 

  • Blair, M. R., and B. B. Clark: J. Pharmacol. exp. Ther. 117, 467 (1956).

    Google Scholar 

  • Bradley, P. B., and B. J. Key: Abstr. XXth Internat. Physiol. Cong. Brüssel 1956, p 124.

  • Brücke, F., S. Sailer u. Ch. Stumpf: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 231, 267 (1957).

    Google Scholar 

  • Dunér, H., U. S. v. Euler u. B. Pernow: Acta physiol. scand. 31, 113 (1954).

    Google Scholar 

  • Euler, U. S. v., B. Pernow: Acta physiol. scand. 36, 265 (1956).

    Google Scholar 

  • Feldberg, W., and M. Vogt: J. Physiol. (Lond.) 107, 372 (1948).

    Google Scholar 

  • Gangloff, H., u. H. Monnier: Acta physiol. pharmacol. neerl. 6, 755 (1957).

    Google Scholar 

  • , u. H. Monnier: Electroenceph. clin. Neurophysiol. 8, 623 (1956).

    Google Scholar 

  • Jung, R., u. A. E. Kornmüller; Arch. Psychiat. Nervenkr. 109, 1 (1939).

    Google Scholar 

  • Kopera, H., u. W. Lazarini: Naunyn Schmiedeberg's Arch. exp. Path. Pharmak. 219, 214 (1953).

    Google Scholar 

  • Lembeck, F.: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 219, 197 (1953); 230, 1 (1956).

    Google Scholar 

  • Monnier, H., u. H. Laue: Helv. physiol. pharmacol. Acta 11, 73 (1953).

    Google Scholar 

  • Moruzzi, G.: Brain Mechanismus and consciouness. Oxfort: Blackwell Scientific Publications 1954.

    Google Scholar 

  • Moruzzi, G., and H. W. Magoun: Electroenceph. clin. Neurophysiol. 1, 455 (1949).

    Google Scholar 

  • Pernow, B.: Acta physiol. scand. 29, Suppl. 105 (1953).

  • Rinaldi, F., and H. E. Himwich: Arch. Neurol. Psychiat. (Chicago) 73, 387, 396 (1955).

    Google Scholar 

  • Sailer, S., u. Ch. Stumpf: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 231, 63 (1957).

    Google Scholar 

  • Stern, R., u. S. Hukovic: Naturwissenschaften 43, 538 (1956).

    Google Scholar 

  • White, R. P., and H. E. Himwich: Amer. J. Physiol. 189, 513 (1957).

    Google Scholar 

  • Zetler, G., u. L. Schlosser: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 224, 159 (1955).

    Google Scholar 

  • Itler, G.: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 228, 513 (1956).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aus dem Pharmakologischen Institut und der Psychiatrisch-Neurologischen Klinik der Universität Graz, Austria

    H. Lechner & F. Lembeck

Authors
  1. H. Lechner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Lembeck
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Mit 3 Textabbildungen

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lechner, H., Lembeck, F. Einfluß der Substanz P auf die elektrische Aktivität des Gehirns. Naunyn - Schmiedebergs Arch 234, 419–425 (1958). https://doi.org/10.1007/BF00258931

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00258931

Search

Navigation