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Independence of drug-induced damage in sarcoma 37 and carotid blood pressure in mice

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Summary

Thirty-seven drugs of various pharmacologic types were examined in CAF1 mice for: a) capacity to induce hemorrhagic-necrosis in Sarcoma 37; and b) the changes induced in systemic blood pressure as continuously recorded with a technic devised for the direct measurement of carotid blood pressure in mice.

Of the ten tumor-damaging drugs, five caused a rise of carotid blood pressure, while three others caused a fall. More than 60% of the drugs which did not damage the tumors produced a lowering of systemic blood pressure.

Induction of tumor-damage with these drugs was found to be independent of the changes they produced in carotid blood pressure.

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Author notes

  1. Sachindra N. Pradhan

    Present address: Department of Pharmacology, Howard University School of Medicine, Washington

Authors and Affiliations

  1. From the Laboratory of Chemical Pharmacology of the National Cancer Institute, Bethesda, Maryland, USA

    Sachindra N. Pradhan, Betty Achinstein & Murray J. Shear

Authors
  1. Sachindra N. Pradhan
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  2. Betty Achinstein
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  3. Murray J. Shear
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Additional information

This paper is dedicated to Professor Rolf Meier, Basle, on the occasion of his 60th birthday anniversary.

National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare.

Preliminary reports (Pradhan, Achinstein and Shear 11, 12) were given at the Fall 1954 and Spring 1955 meetings of the American Society for Pharmacology and Experimental Therapeutics.

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Pradhan, S.N., Achinstein, B. & Shear, M.J. Independence of drug-induced damage in sarcoma 37 and carotid blood pressure in mice. Naunyn - Schmiedebergs Arch 230, 228–235 (1957). https://doi.org/10.1007/BF00258499

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  • DOI: https://doi.org/10.1007/BF00258499

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