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The influence of circadian variations in plasma iron on the measure of plasma iron turnover

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Abstract

In 92 cases studied in vivo with 59Fe, the variations of plasma iron during the study were measured. Errors in calculation of plasma iron turnover of up to 25% can be made in normosideremic patients if such variations are not taken into account. In hypersideremic patients the variations of plasma iron are low or nil; in hyposideremic patients the slow variations of plasma iron concentration do not alter the rapid slope of radio-iron removal.

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References

  1. Bothwell, T.H., Mallett, B.: Diurnal variation in the turnover of iron through the plasma. Clin. Sci. 14, 235–240 (1955)

    Google Scholar 

  2. Cavill, I., Ricketts, C., Napier, J.A.F., Jacobs, A., Trevett, D., Bishop, R.D.: The measurement of 59Fe clearance from the plasma. Scand. J. Haematol. 17, 160–166 (1976)

    Google Scholar 

  3. Fiet, J., Tabuteau, F. Note technique concernant le dosage de la sidérémie à l'auto-analyseur I et au SAM Technicon. Bull. SFBC, 1–3 (1975)

  4. Fillet, M.S., Cook, J.D., Finch, C.A.: Storage iron kinetics. VII — A biological model for reticulo-endothelial iron transport. J. Clin. Invest. 53, 1527–1533 (1974)

    Google Scholar 

  5. Giovanello, T.J., Di Benedetto, G., Palmer D.W., Peters, T.: Fully automated method for the determination of serum iron and T.I.B.C. In Automation in analytical chemistry, pp. 183–187 (1967)

  6. Hosain, F., Marsaglia, G., Finch, C.A.: Blood, ferrokinetics in man. J. Clin. Invest. 46, 1–9 (1967)

    Google Scholar 

  7. Lockner, D.: The diurnal variation of plasma iron turnover and erythropoiesis in healthy subjects and cancer patients. Br. J. Haematol. 12, 646–656 (1966)

    Google Scholar 

  8. Lynch, S.R., Simon, M., Bothwell, T.H., Charlton, R.W.: Circadian variation in plasma iron concentration and reticuloendothelial iron release in the rat. Clin. Sci. Mol. Med. 45, 331–336 (1973)

    Google Scholar 

  9. Najean, Y., Ardaillou, N., Dresch, C.: Utilisation des techniques isotopiques en hématologie. Paris: Baillière 1969

    Google Scholar 

  10. Najean, Y., Dresch, C., Ardaillou, N., Bernard, J.: Iron metabolism. Study of different kinetic models in normal conditions. Am. J. Physiol. 213, 533–539 (1967)

    Google Scholar 

  11. Vahlquist, B.C.: Das Serumeisen. Eine pädiatrisch-klinische und experimentelle Studie. Acta Paed. (Scand.) 28, Suppl. 5 (1941)

  12. I.C.S.H. Proposed recommandation for measurement of serum iron in human blood. Am. J. Clin. Pathol. 56, 543–549 (1971)

    Google Scholar 

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Authors and Affiliations

  1. Service Central de Médecine Nucléaire, Hôpital Saint-Louis, F-75645, Paris Cedex 10, France

    Y. Najean,  Castro-Malaspina, P. Colonna & C. Dresch

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  1. Y. Najean
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  2. Castro-Malaspina
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  3. P. Colonna
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  4. C. Dresch
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Najean, Y., Castro-Malaspina, Colonna, P. et al. The influence of circadian variations in plasma iron on the measure of plasma iron turnover. Eur J Nucl Med 2, 189–191 (1977). https://doi.org/10.1007/BF00257279

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  • DOI: https://doi.org/10.1007/BF00257279

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