Abstract
A new radioisotopic method of determining the separate glomerular clearance of the kidneys is described. After injection of 99mTc-DTPA, the data from a scintillation camera are recorded by computer. The renal curves are corrected for extrarenal activity and the plasma curve is obtained from a precordial curve. At each instant the slope of the renal curve divided by the corresponding plasma concentration gives the separate clearance value, in the period extending from 80 to 180 s after injection of the tracer. The error and correction factors introduced are discussed. Normal values are established on 25 patients and correspond to inulin clearance values. Left kidney: 60 ml/min (SD=13). Right kidney: 57 ml/min (SD=12). The method is simple for the patient, takes only 20 min, is not dangerous, is particularly applicable to young children and can be repeated frequently in the same patient.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barbour, G.L., Crumb, C.K., Boyd, C.M.: Comparison of inulin, iothalamate and 99mTc-DTPA for measurement of glomerular filtration rate. J. nucl. Med. 17, 317–320 (1976)
Billinghurst, M.W.: Chromatographic quality control of 99mTc-labeled compounds. J. nucl. Med. 14, 793–797 (1972)
Blaufox, M.D., Conroy, M.F.: Measurement of renal mean transit time of 131I-Hippuran with external counting. J. nucl. Biol. Med. 12, 107–116 (1968)
Brown, N.J.G., Britton, K.E.: The theory of renography and analysis of results. In: Radionuclides in nephrology, pp. 315–323. New York: Grune and Stratton 1972
Brooke, P., Decostre, P., Cantraine, F.: Early thyroid iodide and pertechnetate kinetics: a compartmental model derived from scintillation camera data. J. nucl. Med. 16, 517 (1975)
Chisholm, G.D., Short, M.D., Glass, H.I.: The measurement of individual renal plasma flows using 123I-Hippuran and the gamma camera. Brit. J. Urol. 46, 591–600 (1974)
Cohen, M.L., Patel, J.K., Baxter, D.L.: External monitoring and plasma disappearance for the determination of renal function: Comparison of effective renal plasma flow and glomerular filtration rate. Pediatrics 48, 377–392 (1971)
Diffey, B.L., Hall, F.M., Corfield, J.R.: The 99mTc-DTPA renal with deconvolution analysis. J. nucl. Med. 17, 352–355 (1976)
Erbsmann, F., Paternot, J., Piepsz, A.: Les erreurs liés à la scintigraphie digitale à la caméra à scintillation. In: C. Raynaud, ed., Ilé Colloque International sur la Fixation rénale du Mercure radioactif, p. 28. Paris: Masson 1975
Farmelant, M.H., Sachs, C.E., Burrows, B.A.: The influence of tissue background radioactivity on the apparent renal accumulation of radioactive compounds. J. nucl. Med. 11, 112–117 (1970)
Handmaker, H.: Methode de la mesure simplifiée de la fonction de chaque rein avec le 99mTc-DMSA. In: C. Raynaud, ed., Ilè Colloque International sur la fixation rénale du Mercure radioactif, p. 225. Paris: Masson 1975
Holroyd, A.M., Chisholm, G.D., Glass, H.I.: The quantitative analysis of renograms using the gamma camera. Phys. in Med. Biol. 15, 483–492 (1970)
James, A.E., Wagner, H.N., Jr., Cooke, R.E.: Pediatric nuclear medicine, p. 42. Philadelphia: Saunders 1974
Kenny, R.W., Ackery, D.M., Fleming, J.S.: Deconvolution analysis of the scintillation camera renogram. Brit. J. Radiol. 48, 481–486 (1975)
Kereiakes, J.G., Wellman, H.N., Tieman, J.: Radiopharmaceutical dosimetry in pediatrics. Radiology 90, 925–930 (1968)
Klopper, J.F., Hauser, W., Atkins, H.L.: Evaluation of 99mTc-DTPA for the measurement of glomerular filtration rate. J. nucl. Med. 13, 107–110 (1971)
Maxwell, M.H., Hayes, M.: The abnormal renogram. A. The renogram and hypertension. In: Progr. nucl. med., pp. 249–259. Baltimore: University Park Press 1972
McHardy-Young, S., Andrews, D.: Correlation of radioisotope renograms with divided renal function studies in hypertensive subjects. In: C. Timmermans and G. Merchie, eds., Radioisotopes in the diagnosis of diseases of the kidney and the urinary tract, pp. 228–233. Amsterdam: Excerpta Medica 1969
Muehllehner, G.: A diverging collimator for gamma-ray imaging cameras. J. nucl. Med. 10, 197–201 (1968)
Nimmon, C.C., Mc Alister, J.M., Cattell, W.R.: Kidney position and the measurement of relative uptake of 131I-Hippuran in renography. Brit. J. Radiol. 48, 286–290 (1975)
Piepsz, A., Erbsmann, F., Vainsel, M., Cantraine, F.: Determination of glomerular filtration rate in children by external measurement of the disappearance of 113m-Indium-DTPA in plasma. Biomedicine 20, 192–197 (1974)
Raynaud, C.: La fixation rénale du Mercure radioactif, pp. 46–48. Paris: Masson 1973
Raynaud, C., Desgrez, A., Kellerman, C.: Measurement of renal uptake by external counting: separate functional testing of each kidney. J. Urol. (Baltimore) 99, 248–263 (1968)
Raynaud, C., Jacquot, C., Freeman, L.M.: Measuring renal uptake of 197 HgCl2 by gamma camera. Radiology 110, 413–417 (1974)
Rohloff, R., Hast, B., Leisner, B., Heinze, H.G.: Bestimmung der 131J-Hippuran-Clearance im Rahmen der Kamerafunktionsszintigraphie der Nieren nach vereinfachten Modifikationen der Methode von Oberhausen. Nucl.-Med. (Stuttg.) 12, 303–320 (1975)
Royer, P., Habib, R., Mathieu, H., Broyer, M.: Néphrologie pédiatrique, pp. 273–275. Paris: Flammarion 1975
Verhas, M., Bossuyt, A.: Valeur de la méthode ultrasonographique dans l'estimation de la profondeur rénale. In: C. Raynaud, ed., Ilè Colloque International sur la fixation rénale du mercure radioactif, pp. 62–72. Paris: Masson 1975
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Piepsz, A., Dobbeleir, A. & Erbsmann, F. Measurement of separate kidney clearance by means of 99mTc-DTPA complex and a scintillation camera. Eur J Nucl Med 2, 173–177 (1977). https://doi.org/10.1007/BF00257276
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00257276