The imaging of myocardial perfusion with ^81mKr during coronary arteriography

Abstract

The use of ^81mKr was investigated for imaging myocardial perfusion during coronary arteriography using conventional catheters. When the significance of stenosis judged by arteriography is unclear, the effect on tissue perfusion can be established and the contribution to collateral flow by each artery separately evaluated. The distribution of ^81mKr, due to its 13-s half-life, represents regional blood flow. In order to evaluate interventions, studies can be repeated at a low radiation risk to patients. A sterile pyrogenfree ⁸¹Rb−⁸¹Kr generator was developed. With slow infusion, inadequate mixing and streaming takes place due to laminar flow in coronary arteries. Fast intermittent 3-ml ⁸¹Kr-dextrose bolus injections convincingly eliminated streaming artefacts. Imaging was performed in 13 patients with a mobile scintillation camera and digital imaging system. Blood flow was calculated using the inert gas washout technique. There was good correlation (r=0.91) between coronary blood flow determinations using ^81mKr and ¹³³Xe respectively. The perfusion images correlated well with the coronary angiograms. Total coronary arterial occlusions as demonstrated by arteriography were all shown as perfusion defects during rest. During atrial pacing myocardial flow was increased two-fold in normal coronary arteries and to a lesser extent in arteries with significant disease. The most critical lesion in a branch of a left coronary artery leads to a redistribution of perfusion during pacing.