Summary
Ten adult male mongrel dogs were inoculated with Chlamydia trachomatis by injections of 106 or 107 organisms directly into the prostate. We were able to recover Chlamydia 3 to 7 days later in three of four dogs receiving injections of 107 organisms. Eight of ten dogs developed detectable serum antibody to Chlamydia 14 to 68 days following inoculation. All dogs receiving 107 Chlamydia and two of six dogs receiving 106 organisms developed histological signs of prostatic hyperplasia. Thus, the dog may be a model for establishment of chlamydial prostatitis and may be used for further investigations of this disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berger RE, Alexander ER, Harnisch JP, Paulsen CA, Monda GD, Ansell J, Holmes KK (1979) Etiology, manifestations and therapy of acute epididymitis: Prospective study 50 case. J Urol 121:750
Digiacomo RF, Gale JL, Wange S-P, Kiviat MD (1975) Chlamydial infection of the male baboon urethra. Br J Vener Dis 51: 310
Hofstetter A (1979) The role of Chlamydiae in the male urethroadnexitis. Infection 7 (Suppl 2) p 228
Mårdh P-A, Colleen S (1975) Search for uro-genetial tract infections in patients with symptoms of prostatitis. Scand J Urol Nephrol 9:361 (1975)
Mårdh P-A, Colleen S, Holmquist B (1972) Chlamydia in chronic prostatitis. Br Med J 4:361
Mårdh P-A, Ripa KT, Colleen S, Treharne JD, Darougar S (1978) Role of Chlamydia trachomatis in non-acute prostatitis. Br J Vener Dis 54:330
McComb DE, Puzniak CI (1974) Micro cell culture method for isolation of Chlamydia trachomatis. Appl Environ Microbiol 28:727
Mostofi FK (1970) Benign hyperplasia of the prostate gland. In: Campbell MF, Harrison JH (eds) Urology, Saunders, Philiadelphia, p 1073
Richmond SJ, Sparling PF (1976) Genital chlamydial infections. Am J Epidemiol 103:428
Ripa KT, Mårdh P-A (1977) Cultivation of Chlamydia trachomatis in cycloheximide treated McCoy cells. J Clin Microbiol 6:328
Schachter J (1978) Chlamydial infections. N Engl J Med 298: 428
Zachariae H, From E, Zachariae E (1979) Reiter's disease and prostatitis. Treatment with tetracycline. Ugeskr Laeger 141: 2058
Zuckerman S, Groome JR (1937) The aetiology of benign enlargement of the prostate in the dog. J Path 44:113
Author information
Authors and Affiliations
Additional information
This project was suppored in part by the Veterans Administration
Rights and permissions
About this article
Cite this article
Nielsen, O.S., Golubjatnikov, R., Dodge, R. et al. Chlamydial prostatitis in dogs: An experimental study. Urol. Res. 10, 45–49 (1982). https://doi.org/10.1007/BF00256524
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00256524