Abstract
99mTc-MAG3 has been proposed as a replacement for both 131I-hippuran and 99mTc-DTPA on clinical grounds. We undertook a prospective preliminary study to ascertain whether 99mTc-MAG3 works better than 99mTc-DTPA in the follow up of renal transplant recipients. Seventeen patients (21 renograms each MAG3 and DTPA) were studied, together, with a reference group of 10 patients in whom MAG3 and Hippuran clearance rates were determined simultaneously. As expected, 99mTc-MAG3 analog images were excellent and 99mTcMAG3 clearance correlated very well with 131I-hippuran clearance (r=0.978). MAG3 values were 60% of hippuran values. However, when the corresponding renographic and perfusion findings were faced with different diagnostic challenges, such as post transplant renal failure and rejection, 99mTc MAG3 did not differ from 99mTc-DTPA in a significant way. 99mTc-DTPA was superior to 99mtc-MAG3 in one case of rejection.
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Al-Nahhas A, Jafri RA, Britton KE, Solanki K, Bomanji J, Mather S, Carroll MA, Al-Janabi M, Frusciante V, Ajdinovic B, Fiore F, Demena S, Nimmon CC (1988) Clinical experience with 99m-Tc-MAG3, mercaptoacetyltriglycine, and a comparison with 99m-Tc-DTPA. Eur J Nucl Med 14:453–462
Bubeck B, Brandau W, Eisenhut M, Weidenhammer K, Georgi P (1987) The tubular Extraction Rate (TER) of 99m-Tc-MAG3: A new quantitative parameter of renal function. Nuc Compac 18:260–265
Hilson AJW, Maisey MN, Brown CB, Ogg CS, Bewick MS (1978) Dynamic renal transplant imaging with Tc-99m-DTPA (Sn) supplemented by a transplant perfusion index in the management of renal transplants. J Nucl Med 19:994–1000
Jafri RA, Britton KE, Nimmon CC, Solanki K, Al-Nahhas AA, Bomanji J, Fettich J, Hawkins LA (1988) Technetium-99m MAG3, a comparison with Iodine-123 and Iodine-131 Orthoiodohippurate, in patients with renal disorders. J Nucl Med 29:147–158
Rusell CD, Thorstad B, Yester MV, Stutzman M, Baker T, Duvobsky E (1988) Comparison of technetium-99m MAG3 with Iodine-131 hippuran by a simultaneous dual channel technique. J Nucl Med 29:1189–1193
Taylor A, Eshima D, Fritzberg AR, Christian PE, Kasina S (1986) Comparison of Iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers. J Nucl Med 27:795–803
Taylor A, Eshima D, Alazraki N (1987) 99m-Tc-MAG3, a new renal imaging agent: Preliminary results in patients. Eur J Nucl Med 12:510–514
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Fraile, M., Castell, J., Buxeda, M. et al. Transplant renography: 99m-Tc-DTPA versus 99m-Tc-MAG3. a preliminary note. Eur J Nucl Med 15, 776–779 (1989). https://doi.org/10.1007/BF00255496
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DOI: https://doi.org/10.1007/BF00255496