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Bioactive polymers

XLII. Coupling of ampicilline on(chlorocarbonylmethyl)cellulose

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Summary

In the present paper the coupling of ampicilline on (chlorocarbonylmethyl)cellulose is studied. The reaction is influenced by the drug/support mole ratio, duration and solvent volume (DMSO). The dependence of the coupling yield on the above — mentioned parameters is described fairly by a regression equation of the second order whose coefficients were settled by the multiple regression method. The obtained products are polymer drugs with retard antimicrobial action.

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Authors and Affiliations

  1. Department of Organic and Macromolecular Chemistry, Polytechnic Institute of Jassy, RO-6600, Jassy, Romania

    Cristofor I. Simionescu, Severian Dumitriu, Marcel Popa & Maria Dumitriu

Authors
  1. Cristofor I. Simionescu
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  2. Severian Dumitriu
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  3. Marcel Popa
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  4. Maria Dumitriu
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Simionescu, C.I., Dumitriu, S., Popa, M. et al. Bioactive polymers. Polymer Bulletin 16, 319–325 (1986). https://doi.org/10.1007/BF00255003

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  • DOI: https://doi.org/10.1007/BF00255003

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