Abstract
Prostaglandin E1 was administered intravenously to 10 patients who had the adult respiratory distress syndrome associated with severe infection in order to investigate its hemodynamic effects. Infusion of PGE1 significantly decreased the mean pulmonary arterial pressure, mean systemic arterial pressure, pulmonary vascular resistance and systemic vascular resistance, and increased the cardiac index, oxygen delivery and oxygen consumption. No significant difference was noted in the intrapulmonary shunt fraction. These results indicate that administration of PGE1 improves pulmonary hemodynamics and tissue oxygenation in patients with acute respiratory distress syndrome, by reducing right ventricular afterload and increasing the cardiac index.
Similar content being viewed by others
References
Benumof JL (1979) Hypoxic pulmonary vasoconstriction and infusion of sodium nitroprusside. Anesthesiology 50:481
Clowes GHA Jr, Hirsch E, Williams L, Kwasnik E, O'Donnell TF, Cuevas P, Saini VK, Moradi I, Farizan M, Saravis C, Stone M, Kuffler J (1975) Septic lung and shock lung in man. Ann Surg 181:681
Danek SJ, Lynch JP, Weg JG, Dantzker DR (1980) The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome. Am Rev Respir Dis 122:387
Gallagher TJ, Civetta JM (1981) Normal pulmonary vascular resistance during acute respiratory insufficiency. Crit Care Med 9:647
Klausen NO, Qvist J, Brynjolf I, Munck O, Sørensen B, Wiberg-Jørgensen F (1982) Pulmonary hypertension in a patient with ARDS—a possible side-effect of dopamine treatment. Intensive Care Med 8:155
Naeije R, Mélot C, Mols P, Hallemans R (1982) Reduction in pulmonary hypertension by prostaglandin E1 in decompensated chronic obstructive pulmonary disease. Am Rev Respir Dis 125:1
Pearl RG, Rosenthal MH, Ashton JPA (1983) Pulmonary vasodialator effects of nitroglycerin and sodium nitroprusside in caine oleic acid-induced pulmonary hypertension. Anesthesiology 58:514
Poweres SR, Mannal R, Neclerio M, English M, Marr C, Leather R, Veda H, Williams G, Custead W, Dutton R (1973) Physiologic consequences of positive end-expiratory pressure (PEEP) ventilation. Ann Surg 178:265
Prewitt RM, Wood LDH (1981) Effect of sodium nitroprusside on cardiovascular function and pulmonary shunt in caine oleic acid pulmonary edema. Anesthesiology 55:537
Prewitt RM, Ghighone M (1983) Treatment of right ventricular dysfunction in acute respiratory failure. Crit Care Med 11:346
Simonneau G, Escourrou P, Duroux P, Lockhart A (1981) Inhibition of hypoxic pulmonary vasoconstriction by nifedipine. N Engl J Med 304:1582
Zapol WM, Snider MT (1977) Pulmonary hypertension in severe acute respiratory failure. N Engl J Med 296:476
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tokioka, H., Kobayashi, O., Ohta, Y. et al. The acute effects of prostaglandin E1 on the pulmonary circulation and oxygen delivery in patients with the adult respiratory distress syndrome. Intensive Care Med 11, 61–64 (1985). https://doi.org/10.1007/BF00254775
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00254775