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Microsphere angiography in hepatic artery infusion for cancer

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Abstract

99mTc-human albumin microspheres were injected at a slow flow rate into the hepatic arteries of 24 patients before starting intraarterial chemotherapy for liver cancer. The distribution patterns of radiolabeled microspheres were significantly different from those obtained in contrast angiography in 13 of 22 patients. Liver uptake of slowly injected microspheres was greater than 75% in 16 of 24 patients and less than 25% in 4 of 24 patients. A significantly increased arterial blood supply to intrahepatic neoplastic regions was demonstrated in 12 of 20 patients. Microsphere examination allowed an easy evaluation of the relative perfusion of the liver and of the intrahepatic distribution of arterial blood flow in all patients.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Istituto Nazionale per lo Studio, Via Venezian 1, I-20133, Milan, Italy

    A. Rodari & G. L. Buraggi

  2. Department of Clinical Oncology, Istituto Nazionale per lo Studio, Via Venezian 1, I-20133, Milan, Italy

    G. Bonfanti & R. Marolda

  3. Department of Radiology, Istituto Nazionale per lo Studio, Via Venezian 1, I-20133, Milan, Italy

    F. Garbagnati & M. Milella

  4. la Cura dei Tumori, Via Venezian 1, I-20133, Milan, Italy

    F. Garbagnati & M. Milella

Authors
  1. A. Rodari
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  2. G. Bonfanti
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  3. F. Garbagnati
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  4. R. Marolda
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  5. M. Milella
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  6. G. L. Buraggi
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Rodari, A., Bonfanti, G., Garbagnati, F. et al. Microsphere angiography in hepatic artery infusion for cancer. Eur J Nucl Med 6, 473–476 (1981). https://doi.org/10.1007/BF00252806

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  • DOI: https://doi.org/10.1007/BF00252806

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