Abstract
To clarify the mechanism of the elimination of radioactivity after administration of radioiodinated heptadecanoic acid, dogs with and without coronary occlusion were studied. In myocardial tissue samples of normal and ischemic myocardium, the proportions of free radioiodide, radioiodinated heptadecanoic acid, and radioiodinated lipids were determined. Five minutes after intravenous injection of heptadecanoic acid 69% of the radioactivity was present as free iodine, 7% as unaltered heptadecanoic acid, and 24% as lipids. Even in ischemic myocardium 41% was free iodine and 47% lipids. After 2 h free iodine decreased to 48% and lipids increased to 44%. These results indicate that beta-oxidation is not the rate-limiting step in the elimination rate of heptadecanoic acid.
Similar content being viewed by others
References
Feinendegen LE, Vyska K, Freundlieb C, Hoeck A, Machulla HJ, Kloster G, Stoecklin G (1981) Non-invasive analysis of metabolic reactions in body tissues, the case of myocardial fatty acids. Eur J Nucl Med 6:191–200
Freundlieb C, Hoeck A, Vyska K, Feinendegen LE, Machulla HJ, Stoecklin G (1980) Myocardial imaging and metabolic studies with [17-I-123]iodoheptadecanoic acid. J Nucl Med 21:1043–1050
Kloster G, Stoecklin G (1982) Determination of the rate-determining step in halofatty acid-turnover in the heart. In: Radioaktive Isotope in Klinik und Forschung (Ed Egermann) 15:235–241
Liedtke AJ (1981) Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 23:321–336
Machulla HJ, Stoecklin G, Kupfernagel C, Freundlieb C, Hoeck A, Vyska K, Feinendegen LE (1978) Comparative evaluation of fatty acids labeled with C-11, Cl-34m, Br-77 and I-123 for metabolic studies of the myocardium: concise communication. J Nucl Med 19:298–302
Opie LH (1979) Role of carnitine in fatty acid metabolism of normal and ischemic myocardium. Am Heart J 97:375–388
Otto CA, Brown LE, Wieland DM, Beierwaltes WH (1981) Radioiodinated fatty acids for myocardial imaging: Effects of chain length. J Nucl Med 22:613–618
Poe ND, Robinson jr GD, Graham LS, MacDonald NS (1976) Experimental basis for myocardial imaging with I-123-labeled hexadecenoic acid. J Nucl Med 17:1077–1082
Poe ND, Robinson jr GD, Zielinski FW, Cabeen jr WR, Smith JW, Gomes AS (1977) Myocardial imaging with I-123-hexadecenoic acid. Radiology 124:419–424
Robinson jr GD, Lee AW (1975) Radioiodinated fatty acids for heart imaging: iodine monochloride addition compared with iodide replacement labeling. J Nucl Med 16:17–21
Rose CP, Goresky GA (1977) Constraints on the uptake of labeled palmitate by the heart. The barriers at the capillary and sarcolemmal surfaces and the control of intracellular sequestration. Circ Res 41:534–545
Sobel BE, Weiss ES, Welch MJ, Siegel BA, Ter-Pogossian MM (1977) Detection of remote myocardial infarction in patients with positron emission transaxial tomography and intravenous C-11-palmitate. Circulation 55:853–857
Van der Wall EE, Heidendal GAK, Den Hollander W, Westera G, Roos JP (1980) I-123 labeled hexadecenoic acid in comparison with thallium-201 for myocardial imaging in coronary heart disease. A preliminary study. Eur J Nucl Med 5:401–405
Van der Wall EE, Heidendal GAK, Den Hollander W, Westera G, Roos JP (1981b) Metabolic myocardial imaging with I-123 labeled heptadecanoic acid in patients with angina pectoris. Eur J Nucl Med 6:391–396
Van der Wall EE, Den Hollander W, Heidendal GAK, Westera G, Majid PA, Roos JP (1981a) Dynamic myocardial scintigraphy with I-123 labeled free fatty acids in patients with myocardial infarction. Eur J Nucl Med 6:383–389
Van der Wall EE, Westera G, Den Hollander W, Visser FC (1981c) External detection of regional myocardial metabolism with radioiodinated hexadecenoic acid in the dog heart. Eur J Nucl Med 6:147–151
Vusse GJ van der, Roemen THM, Prinzen FW, Coumans WA, Reneman RS (1982) Uptake and tissue content of fatty acids in dog myocardium under normoxic and ischemic conditions. Circ Res 50:538–546
Weishaar R, Ashikawa K, Bing RJ (1979) Effect of diltiazem, a calcium antagonist, on myocardial ischemia. Am J Cardiol 43:1137–1143
Westera G, Van der Wall EE, Heidendal GAK, Van den Bos GC (1980) A comparison between terminally radioiodinated hexadecenoic acid (I-HA) and Tl-201-thallium chloride in the dog heart. Implications for the use of I-HA for myocardial imaging. Eur J Nucl Med 5:339–343
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Visser, F.C., Westera, G., van Eenige, M.J. et al. The myocardial elimination rate of radioiodinated heptadecanoic acid. Eur J Nucl Med 10, 118–122 (1985). https://doi.org/10.1007/BF00252717
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00252717