Abstract
A new isotopic method for evaluation of inflammatory activity in rheumatoid arthritis is reported. By use of repeated whole body profile scanning a double tracer examination with 99mTc-pertechnetate and 113mIn-transferrin was performed. Total pertechnetate activity and total indium activity were measured over both hands, both feet, the ankles, and over the knee joints. In addition, the extravascular component of pertechnetate uptake and the ratio extravascular/total pertechnetate activity were calculated for these regions. The activity curves were followed up to 2 h after tracer injection in seven female patients presenting with rheumatoid arthritis and in six female controls. The four parameters calculated were compared and statistical analysis revealed the most significant discrimination of both groups for the ratio extravascular/total pertechnetate activity 2 h after injection (P(0.002).
Similar content being viewed by others
References
A Committee of the American Rheumatism Association: Diagnostic criteria for rheumatoid arthritis. 1958 Revision. Ann. rheum. Dis. 18, 49 (1959)
Bergmann, H., Höfer, R.: Aufbau und Kenndaten eines klinischen Ganzkörperzählers nach dem Shadow-Shield-Prinzip. In: Quality factors in nuclear medicine, pp. 46.1–56.8. Copenhagen: Proc. Symp. 1975
Berry, H., Browett, J.P., Huskisson, E.C., Bacon, P.A., Willoughby, D.A.: Measurement of Inflammation. I. Application of technetium clearance to rheumatoid arthritis and animal models. Ann. rheum. Dis. 32, 95 (1973)
Berry, H., Huskisson, E.C.: Isotopic indices as a measure of inflammation in rheumatoid arthritis. Ann. rheum. Dis. 33, 523 (1974)
Collins, K.E., Deodhar, S., Nuki, G., Whaley, K., Buchanan, W.W., Dick, W.C.: Radioisotope study of small joint inflammation in rheumatoid arthritis. Radioactive technetium (99mTc) uptake in the proximal interphalangeal joints and the effects of oral corticosteroids. Ann. rheum. Dis. 30, 401 (1971)
Oka, M., Rekonen, A., Ruotsi, A., Kuikka, J.: Measurement of systemic inflammatory activity in rheumatoid arthritis by the 99(m) Tc method. Scand. J. Rheumatol. 2, 101 (1973)
Ritchie, D.M., Boyle, J.A., McInnes, J.M., Jasani, M.K., Dalakos, T.D., Grieveson, P., Buchanan, W.W.: Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Quart. J. Med. NS 37, 393 (1968)
Steinbrocker, O., Traeger, C.H., Batterman, R.C.: Therapeutic criteria in rheumatoid arthritis. J. Amer. med. Ass. 140, 659 (1949)
Tothill, P., Galt, J.: Quantitative profile scanning for the measurement of organ radioactivity. Phys. Med. Biol. 16, 625 (1971)
Weiss, T.E., Maxfield, W.S., Murison, P.J., Hidalgo, J.U.: Scintillation scanning in rheumatoid arthritis. Sth. med. J. (Bgham, Ala.) 59, 484 (1966)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bergmann, H., Kolarz, G. Pertechnetate uptake of joints in rheumatoid arthritis. Eur J Nucl Med 1, 205–210 (1976). https://doi.org/10.1007/BF00252165
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00252165