Summary
Histaminergic neurons of the brain have been implicated in genetic hypertension. We investigated the effect of inhibition of histamine synthesis by α-fluoromethylhistidine (α-FMH), the irreversible inhibitor of histidine decarboxylase, on the development and maintenance of hypertension in spontaneously hypertensive rats.
Young (3-week-old) and adult (7-week-old) rats were treated with α-fluoromethylhistidine for 29 and 13 days, respectively. Treatment of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats with α-fluoromethylhistidine led to a pronounced decrease in the histidine decarboxylase activity and in the histamine concentration in the brain (hypothalamus, brainstem, cortex —midbrain). In adult spontaneously hypertensive rats, the development of hypertension was not influenced by α-fluoromethylhistidine. In young spontaneously hypertensive rats, α-fluoromethylhistidine led to a transient delay in the development of hypertension which was followed by a transient tendency to increased blood pressure.
It is concluded that histaminergic neurons of the brain play only a subordinate role, if any at all, in the development of hypertension in spontaneously hypertensive rats.
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This work was supported by the Fonds zur Förderung der wissenschaftlichen Forschung
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Prast, H., Philippu, A. Does brain histamine contribute to the development of hypertension in spontaneously hypertensive rats?. Naunyn-Schmiedeberg's Arch Pharmacol 343, 307–310 (1991). https://doi.org/10.1007/BF00251131
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DOI: https://doi.org/10.1007/BF00251131