Summary
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1.
Isometric systolic tension (I.S.T.) was measured in the papillary muscle of the cat-heart at temperatures of 37° C, 27° C and 41° C, before and after administration of g-Strophanthine.
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2.
In the majority of experiments an increase in temperature was associated with a decrease of I.S.T.
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3.
g-Strophanthine in concentrations of 0.05–0.2 μ/ml increased the I.S.T. of the failing papillary muscle at 37° C, but did not change the I.S.T. at 27° C and 41° C.
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4.
It is assumed that induction of hypothermia as such compensates for the failure of the papillary muscle which is necessary for the action of cardiac glycosides.
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Literatur
Catell, McK., and H. Gold: The influence of digitalis glycosides on the force of contraction of mammalian cardiac muscle. J. Pharmacol. exp. Ther. 62, 116 (1938).
Cotten, M. de V., and Th. G. Brown jr.: Effects of pressor amines and ouabain on the heart and blood pressure during hypothermia. J. Pharmacol. exp. Ther. 121, 319 (1957).
Covino, B. G., and A. H. Hegnauer: Electrolytes and ph changes in relation to hypothermic ventricular fibrillation. Circulat. Res. 3, 575 (1955).
Garb, S., and M. B. Chenoweth: Electrogram of isolated papillary muscle of the cat heart. Amer. J. Physiol. 156, 27 (1949).
Gollan, F., G. G. Rudolph and N. S. Oslen: Electrolyte transfer during hypothermia and anoxia in dogs. Amer. J. Physiol. 189, 277 (1957).
Hajdu, St., and E. Leonard: The cellular basis of cardiac glycoside action. Pharmacol. Rev. 11, 173 (1959).
Häusler, H. F., u. M. Wieland: Die Wirkung von g-Strophanthin am Herz-Lungen-präparat des Meerschweinchens bei Hypothermie, Normaltemperatur und Hyperthermie. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 242, 403 (1962).
Kukovetz, W.: Die Leistungsreserve des hypothermen Herzmuskels am Herz-Lungen-Präparat der Ratte. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 221, 496 (1957).
Peters, H. P., and M. B. Visscher: The energy metabolism of the heart in failure and the influence of drugs upon it. Amer. Heart J. 11, 273 (1936).
Reissmann, K. R., and R. L. van Citters: Oxygen consumption and mechanical efficiency of the hypothermic heart. J. appl. Physiol. 9, 427 (1956).
Satoskar, R. S., and J. C. Trivedi: The effect of intravenous digitalis on cats under hypothermia. Arch. int. Pharmacodyn. 104, 417 (1955).
Saunders, P. R., and P. N. Sanyal: Effect of temperature upon the positive inotropic action of ouabain. J. Pharmacol. exp. Ther. 123, 161 (1958).
Tardos, L.: Untersuchungen am Papillarmuskel des Säugetierherzens. Acta physiol. Acad. Sci. 7, 319 (1955).
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Herr Prof. Dr. A. Jarisch zum 70. Geburtstag gewidmet.
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Meyer, H.F., Kukovetz, W.R. Die Wirkung von g-Strophanthin auf den Papillarmuskel der Katze bei Hypothermie, Normaltemperatur und Hyperthermie. Naunyn - Schmiedebergs Arch 242, 409–413 (1962). https://doi.org/10.1007/BF00247965
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DOI: https://doi.org/10.1007/BF00247965