Skip to main content
SpringerLink
Log in

Die Wirkung von Pyramidon auf die Entladung der Muskelspindeln beim Streckreflex

  • Published:
Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie Aims and scope Submit manuscript

Summary

The effect of pyramidone upon the discharge frequency of muscle spindles was studied in cats decerebrated by intercollicular section and after spinalization Spindle discharge was recorded before and during stretch of the soleus and gastrocnemius muscles.

Spindle activity was increased by pyramidone in the spinalized preparation.

In decerebrate cats the drug not only increased but nearly as often also reduced discharge frequency. Decreased spindle activity was generally accompanied by diminished reflex tension of the muscles and vice versa. In some few cases, however, the changes in spindle activity and muscle tension did not run parallel.

It is suggested that depression of myotatic reflexes caused by pyramidone in the decerebrate cat is not due to an inhibition of the spinal γ-motor system, but results from a supraspinal inhibitory mechanism working upon both α and γ systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Cook, L., and D. D. Bonnycastle: An examination of some spinal and ganglionic actions of analgetic materials. J. Pharmacol. exp. Ther. 109, 35–44 (1953).

    Google Scholar 

  • Eldred, E., R. Granit and P. A. Merton: Supraspinal control of the muscle spindles and its significance. J. Physiol. (Lond.) 122, 498–523 (1953).

    Google Scholar 

  • Granit, R.: Receptors and Sensory Perception. New Haven: Yale University Press 1955.

    Google Scholar 

  • —Symposium on Muscle Receptors. University of Hong Kong Golden Jubilee Congress, Sept. 1961. Hong Kong University Press 1962.

  • Henatsch, H. D., u. D. H. Ingvar: Chlorpromazine und Spastik. Eine experimentelle elektrophysiologische Untersuchung. Arch. Psychiat. Nervenkr. 195, 77–93 (1956).

    Google Scholar 

  • Jurna, I.: Die Wirkung von 1-Phenyl-2,3-dimethyl-4-dimethyl-aminopyrazolon (Pyramidon) und 1-Phenyl-2,3-dimethyl-4-isopropylaminopyrazolon (Isopyrin) auf spinale Reflexe. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 245, 305–320 (1963).

    Google Scholar 

  • Matthews, P. B. C., and G. Rushworth: The selective effect of procaine on the stretch reflex and tendon jerks of soleus muscle when applied to its nerve. J. Physiol. (Lond.) 135, 245–262 (1957a).

    Google Scholar 

  • — The relative sensitivity of muscle nerve fibres to procaine. J. Physiol. (Lond.) 135, 263–269 (1957b).

    Google Scholar 

  • Sherrington, C. S.: On reciprocal innervation of antagonistic muscles. Tenth note. Proc. roy. Soc. B 79, 337–349 (1907).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Universität des Saarlandes, Homburg/Saar

    Ilmar Jurna

Authors
  1. Ilmar Jurna
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Mit 6 Textabbildungen

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jurna, I. Die Wirkung von Pyramidon auf die Entladung der Muskelspindeln beim Streckreflex. Naunyn - Schmiedebergs Arch 246, 287–296 (1963). https://doi.org/10.1007/BF00247451

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00247451

Search

Navigation