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The Effect of Transcutaneous Electrical Spinal Cord Stimulation on the Functional Activity of Spinal Inhibition in the System of Synergistic Muscles of the Lower Leg in Humans

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Abstract

The effect of 20-minute transcutaneous electrical spinal cord stimulation (tESCS) on the severity of nonreciprocal and recurrent inhibition of spinal α-motoneurons in humans at rest and during a weak muscular effort was studied. It was found that during the entire time of exposure to tESCS at rest, the nonreciprocal and recurrent inhibition of the α-motoneurons of the synergist muscle (m. soleus) weakened, inverting to nonreciprocal and recurrent facilitation. Nonreciprocal facilitation of the soleus α-motorneurons was maintained throughout the entire after effect and recurrent facilitation was inverted to recurrent inhibition, which increased up to 20 min after the end of stimulation. The retention of a weak muscular effort during spinal cord stimulation was accompanied by an increase in nonreciprocal and recurrent inhibition of α-motoneurons of the synergist muscle. This post-activation effect lasted up to 20 min after electrical stimulation of the spinal cord. The activity of recurrent inhibition was more pronounced during spinal cord stimulation when performing a weak voluntary effort, and the post-activation effect was manifested by similar changes in the severity of recurrent and nonreciprocal inhibition: their enhancement occurred within 10 min and weakening at 20 min after the end of stimulation to background values. The reflex mechanisms of descending supraspinal and ascending peripheral influences on the functional activity of nonreciprocal and recurrent inhibition in the system of lower leg synergistic muscles in humans based on the effects of tESCS are discussed.

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REFERENCES

  1. Bikmullina, R.Kh., Rozental’, A.N., and Pleshchinskii, I.N., Inhibitory systems of the spinal cord in the control of interactions of functionally coupled muscles, Hum. Physiol., 2007, vol. 33, no. 1, p. 105.

    Article  Google Scholar 

  2. Chelnokov, A.A. and Gorodnichev, R.M., Zakonomernosti formirovaniya spinal’nogo tormozheniya u cheloveka (Pattern of Development of Spinal Inhibition in a Man), Moscow: INFRA-M, 2020.

  3. Hunt, C.C. and Kuffler, S.W., Stretch receptor discharges during muscle contraction, J. Physiol., 1951, vol. 113, p. 298.

    Article  CAS  Google Scholar 

  4. Haase, J., Cleveland, S., and Ross, H.G., Problems of postsynaptic autogenous and recurrent inhibition in the mammalian spinal cord, Rev. Physiol. Biochem. Pharmacol., 1975, vol. 73, p. 74.

    Google Scholar 

  5. Pierrot-Deseilligny, E. and Burke, D., The Circuitry of the Human Spinal Cord: Spinal and Corticospinal Mechanisms of Movement, Cambridge: Cambridge Univ. Press, 2012.

    Book  Google Scholar 

  6. Windhorst, U., Muscle proprioceptive feedback and spinal networks, Brain Res. Bull., 2007, vol. 73, nos. 4–6, p. 155.

    Article  CAS  Google Scholar 

  7. Kudina, L.P. and Piotkevich, M., Analysis of recurrent inhibition innervating fast muscles in humans, Neiroinformatika, 2006, part 1, p. 137.

  8. Obeidat, A.Z., New insights into the spinal recurrent inhibitory pathway normally and after motoneuron regeneration, PhD Thesis, Dayton, OH: Wright State Univ., 2013.

  9. Barrué-Belou, S., Marque, P., and Duclay, J., Supraspinal control of recurrent inhibition during anisometric contractions, Med. Sci. Sports Exercise, 2019, vol. 51, no. 11, p. 2357.

    Article  Google Scholar 

  10. Gerasimenko, Y., Gorodnichev, R., Machueva, E., et al., Novel and direct access to the human locomotor spinal circuitry, J. Neurosci., 2010, vol. 30, no. 10, p. 3700.

    Article  CAS  Google Scholar 

  11. Gorodnichev, R.M., Pivovarova, E.A., Puhov, A., et al., Transcutaneous electrical stimulation of the spinal cord: a noninvasive tool for the activation of stepping pattern generators in humans, Hum. Physiol., 2012, vol. 38, no. 2, p. 158.

    Article  Google Scholar 

  12. Yafarova, G.G., Militskova, A.D., Shul’man, A.A., et al., The effect of transcranial magnetic stimulation on the responses of the leg muscles caused by transcutaneous electrical stimulation of the spinal cord, Prakt. Med., 2017, no. 8 (109), p. 201.

  13. Roshchina, L.V. and Chelnokov, A.A., The effect of transcutaneous electrical spinal cord stimulation on the functional state of the human motor system, Teor. Prakt. Fiz. Kul’t., 2020, no. 4 (982), p. 30.

  14. Minassian, K., Persy, I., Rattay, F., et al., Posterior root-muscle reflexes elicited by transcutaneous stimulation of the human lumbosacral cord, Muscle Nerve, 2007, vol. 35, no. 3, p. 327.

    Article  Google Scholar 

  15. Dimitrijevic, M., Gerasimenko, Yu., and Pinter, M., Evidence for a spinal central pattern generator in humans, Ann. N.Y. Acad. Sci., 1998, vol. 860, p. 360.

    Article  CAS  Google Scholar 

  16. Harkema, S., Gerasimenko, Y., Hodes, J., et al., Epidural stimulation of the lumbosacral spinal cord enables voluntary movement, standing, and assisted stepping in a paraplegic human, Lancet, 2011, vol. 377, no. 9781, p. 1938.

    Article  Google Scholar 

  17. Yamaguchi, T., Fujiwara, T., Takahara, T., et al., The effects of transcutaneous spinal cord stimulation on spinal reciprocal inhibition in healthy persons, Clin. Neurophysiol., 2017, vol. 128, no. 3, p. 115.

    Article  Google Scholar 

  18. Roshchina, L.V., Gladchenko, D.A., Pivovarova, E.A., and Chelnokov, A.A., Effect of long-term electrical spinal cord stimulation on expression of non-reciprocal inhibition α-motoneurons of human skeletal muscles, Vestn. Ross. Univ. Druzhby Nar., Ser.: Med., 2019, vol. 23, no. 4, p. 390.

    Google Scholar 

  19. Gerasimenko, Yu., Kozlovskaya, I., and Edgerton, V.R., Sensorimotor regulation of movements: novel strategies for the recovery of mobility, Hum. Physiol., 2016, vol. 42, no. 1, p. 90.

    Article  Google Scholar 

  20. Pierrot-Deseilligny, E., Katz, R., and Morin, C., Evidence for IB inhibition in human subjects, Brain Res., 1979, vol. 166, no. 1, p. 176.

    Article  CAS  Google Scholar 

  21. Chelnokov, A.A. and Gorodnichev, R.M., Age-related features in the formation of spinal inhibition of skeletal muscles in males, Hum. Physiol., 2015, vol. 41, no. 6, p. 644.

    Article  Google Scholar 

  22. Rossi, A., Zalaffi, A., and Decchi, B., Heteronymous recurrent inhibition from gastrocnemius muscle to soleus motoneurones in humans, Neurosci. Lett., 1994, vol. 169, nos. 1–2, p. 141.

    Article  CAS  Google Scholar 

  23. Pierrot-Deseilligny, E., Morin, C., Bergego, C., and Tankov, N., Pattern of group I fibre projections from ankle flexor and extensor muscle in man, Exp. Brain Res., 1981, vol. 42, nos. 3–4, p. 337.

    CAS  PubMed  Google Scholar 

  24. Chelnokov, A.A. and Buchatskaya, I.N., Functional features spinal inhibition during voluntary motor activity, Teor. Prakt. Fiz. Kul’t., 2015, no. 6, p. 11.

  25. Chelnokov, A.A., Gladchenko, D.A., Fedorov, S.A., and Gorodnichev, R.M., Age-related parameters of spinal inhibition of skeletal muscles in regulation of voluntary movements in men, Hum. Physiol., 2017, vol. 43, no. 1, p. 38.

    Article  Google Scholar 

  26. Knikou, M., The H-reflex as a probe: pathways and pitfalls, J. Neurosci. Methods, 2008, vol. 171, no. 1, p. 1.

    Article  Google Scholar 

  27. Kubota, S., Uehara, K., Morishita, T., et al., Inter-individual variation in reciprocal Ia inhibition is dependent on the descending volleys delivered from corticospinal neurons to Ia interneurons, J. Electromyogr. Kinesiol., 2014, vol. 24, no. 1, p. 46.

    Article  Google Scholar 

  28. Rhoades, R.A. and Bell, D.R., Medical Physiology: Principles for Clinical Medicine, Philadelphia: Lippincott Williams and Wilkins, 2012, 4th ed.

    Google Scholar 

  29. Korolev, A.A., Functional anatomy of descending motor systems in the normal state and during spastic paresis, Fundam. Issled., 2013, no. 3, p. 92.

  30. Chez, C., The control of movement/posture. Voluntary movement, in Principles of Neural Science, New York: McGraw-Hill, 1999, p. 553.

    Google Scholar 

  31. Fujito, Y. and Aoki, M., Monosynaptic rubrospinal projections to distal forelimb motoneurons in the cat, Exp. Brain Res., 1995, vol. 105, no. 2, p. 181.

    Article  CAS  Google Scholar 

  32. Rossi, A. and Decchi, B., Changes in Ib heteronymous inhibition to soleus motoneurones during cutaneous and muscle nociceptive stimulation in humans, Brain Res., 1997, vol. 774, p. 55.

    Article  CAS  Google Scholar 

  33. Matsugi, A., Mori, N., Uehara, S., et al., Effect of cerebellar transcranial magnetic stimulation on soleus Ia presynaptic and reciprocal inhibition, Neuroreport, 2015, vol. 26, no. 3, p. 139.

    Article  Google Scholar 

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Authors and Affiliations

  1. Velikie Luki State Academy of Physical Education and Sports, Velikie Luki, Russia

    A. A. Chelnokov, L. V. Roshchina, D. A. Gladchenko, E. A. Pivovarova, I. V. Piskunov & R. M. Gorodnichev

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  1. A. A. Chelnokov
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  2. L. V. Roshchina
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  3. D. A. Gladchenko
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  4. E. A. Pivovarova
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  5. I. V. Piskunov
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  6. R. M. Gorodnichev
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Correspondence to A. A. Chelnokov.

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All procedures performed in studies involving human participants were in accordance with the biomedical ethics principles formulated in the 1964 Helsinki Declaration and its later amendments and approved by the local bioethical committee of the Velikie Luki State Academy of Physical Education and Sports (Velikie Luki).

Conflict of interests. The authors declare that they have no conflict of interest.

Informed consent. Each study participant provided a signed voluntary written informed consent after explanation of the potential risks and benefits, as well as the nature of the upcoming study, to him.

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Translated by E. Babchenko

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Chelnokov, A.A., Roshchina, L.V., Gladchenko, D.A. et al. The Effect of Transcutaneous Electrical Spinal Cord Stimulation on the Functional Activity of Spinal Inhibition in the System of Synergistic Muscles of the Lower Leg in Humans. Hum Physiol 48, 121–133 (2022). https://doi.org/10.1134/S0362119722020037

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  • DOI: https://doi.org/10.1134/S0362119722020037

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