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The inhibitory effect of local anesthetics on the excitement elicited by intraventricularly injected morphine

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Summary

Electroencephalographic arousal and behavioral excitation elicited by morphine injected intraventricularly were abolished by local anesthetics introduced into the cerebrospinal fluid. It is suggested that local anesthetics paralyze intraventricular chemoreceptors, stimulation of which is the origin of morphine exicitement.

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Authors and Affiliations

  1. From the Department of Pharmacology, Tottori University, School of Medicine, Yonago, Japan

    Kiyoshi Tanaka & Yoshito Kadowaki

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  1. Kiyoshi Tanaka
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  2. Yoshito Kadowaki
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With 4 Figures in the Text

Dedicated to Professor Otto Krayer on his 65th birthday.

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Tanaka, K., Kadowaki, Y. The inhibitory effect of local anesthetics on the excitement elicited by intraventricularly injected morphine. Naunyn - Schmiedebergs Arch 248, 9–14 (1964). https://doi.org/10.1007/BF00247055

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  • DOI: https://doi.org/10.1007/BF00247055

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