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Nachweis von Oxytyramin (Dopamin) in sympathischen Nerven und Ganglien

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Summary

  1. 1.

    The presence of hydroxy-tyramine in extracts from sympathetic nerves (splenic nerves) and sympathetic ganglia (stellata ganglia) is shown by paper-chromatography and pharmacological assay.

  2. 2.

    The hydroxy-tyramine content of the extracts is nearly 50% of the total amount of catechol-amines.

  3. 3.

    This result indicates that hydroxy-tyramine — formed by the 1(—) dopadecarboxylase of the nervous tissue — is the precursor of the nor-adrenaline in sympathetic nerves and ganglia, and furthermore that the biosynthesis of nor-adrenaline from hydroxy-tyramine will take place in the nervous tissue itself.

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Author information

Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Universität Frankfurt a. M., Germany

    H. J. Schümann

Authors
  1. H. J. Schümann
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Mit 7 Textabbildungen

Kurze Mitteilung siehe H. J. Schümann: Naturwiss. 1956, 37.

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Schümann, H.J. Nachweis von Oxytyramin (Dopamin) in sympathischen Nerven und Ganglien. Naunyn - Schmiedebergs Arch 227, 566–573 (1956). https://doi.org/10.1007/BF00246527

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  • DOI: https://doi.org/10.1007/BF00246527

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