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Über die Natur des Überträgerstoffes vagal-motorischer Magenerregungen

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Summary

  1. 1.

    On the isolated preparation of the vagus and stomach of guineapigs, rabbits and rats atropine abolishes immediately the action of acetylcholine whereas it takes several minutes to abolish the effect of electrical vagal stimulation.

  2. 2.

    On this preparation electrical stimulation of the vagus sets free a substance which contracts an isolated test-ileum suspended in the same Tyrode-bath. The effect of the transmitter is abolished by atropine, enhanced by eserine.

  3. 3.

    The results indicate that also in the digestive tract acetylcholine is the transmitter of parasympathetic-motor nerve impulses; they do not support the view of liberation of an atropine-resistant transmitter. — High doses of tryptamine which on the intestine inhibit the action of 5-oxytryptamine do not influence the effect of electrical vagal stimulation.

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Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Universität Frankfurt a. M., Germany

    K. Greeff & P. Holtz

Authors
  1. K. Greeff
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  2. P. Holtz
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Greeff, K., Holtz, P. Über die Natur des Überträgerstoffes vagal-motorischer Magenerregungen. Naunyn - Schmiedebergs Arch 227, 559–565 (1956). https://doi.org/10.1007/BF00246526

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  • DOI: https://doi.org/10.1007/BF00246526

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