Summary
The NAD, NADP and nicotinamide content of brain has been determined in controls and rats treated with Reserpin, Benzenehexachloride, 3-Acetylpyridine and Scillirosid.
None of the drugs influence the concentration of nicotinamide nor that of the coenzymes.
After injection of 500 mg/kg nicotinamide there is a temporary increase in the nicotinamide and NAD content of the brain without changes in the NADP.
Reserpine potentiates the effect of nicotinamide on the NAD level. There is little increase in nicotinamide content at various times after administration of Reserpine and nicotinamide. The mechanism of stimulation of NAD synthesis by nicotinamide and Reserpine is discussed.
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Abbreviations
- NAD:
-
Nicotinamid-adenindinucleotid
- NADP:
-
Nicotinamid-adenindinucleotidphosphat
- NA:
-
Nicotinsäureamid
- NS:
-
Nicotinsäure
- HCH:
-
Hexachlorcyclohexan.
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Coper, H. Der Gehalt an NAD, NADP und Nicotinsäureamid im Gehirn von Ratten nach Einwirkung zentral wirksamer Pharmaka. Naunyn - Schmiedebergs Arch 244, 420–428 (1963). https://doi.org/10.1007/BF00245077
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DOI: https://doi.org/10.1007/BF00245077