Abstract
Purpose: Evaluate therapeutic results of transcatheter segmental hepatic artery chemo-oily-embolization (segmental TAE) against advanced hepatocellular carcinomas (HCC) accompanied by portal tumor thrombus (PTT).
Methods: Segmental TAE was performed in nine patients with hepatic cirrhosis and advanced HCCs accompanied by PTT. Four subsegmental portal branches were obstructed by PTT in three patients, and two were obstructed in the remaining six patients. TAE was performed into the targeted segmental hepatic artery followed by embolization with gelatin sponge particles.
Results: In one patient undergoing subsequent resection, a marked anticancer effect on the PTT was demonstrated histologically. In the eight other patients who did not undergo subsequent resection, the cumulative survival rates were 67% at 6 months, 44% at 1 year, and 22% at 2 years. No serious complications were noted.
Conclusions: This therapeutic approach is thought to be a useful treatment for HCC with PTT, because it reinforces anticancer effects and can be performed more safely than conventional transcatheter arterial embolization.
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Uchida H, Ohishi H, Matsuo N, Nishimine K, Ohue S, Nishimura Y, Maeda M, Yoshioka T (1990) Transcatheter hepatic segmental arterial embolization using Lipiodol mixed with an anticancer drug and Gelfoam particles for hepatocellular carcinoma. Cardiovasc Intervent Radiol 13:140–145
Matsui O, Kadoya M, Yoshikawa J, Gabata T, Arai K, Demachi H, Miyayama S, Takashima T, Unoura M, Kogayashi K (1993) Small hepatocellular carcinoma: Treatment with subsegmental transcatheter arterial embolization. Radiology 188:79–83
Ohishi H, Yosimura H, Uchida H, Sakaguchi H, Yoshioka T, Ohue S, Matsui T, Takaya A, Tsujii T (1989) Transcatheter arterial embolization using iodized oil (lipiodol) mixed with an anticancer drug for hepatocellular carcinoma. Cancer Chemother Pharmacol 23(suppl):33–36
Nakamura H, Hashimoto T, Oi H, Sawada S (1989) Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 170:783–786
Takayasu K, Shima Y, Muramatsu Y, Moriyama N, Yamada T, Makuuchi M, Hasegawa H, Hirohashi S (1987) Hepatocellular carcinoma: Treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology 162:345–351
Ryu M, Yamamoto Y, Yamamoto H, Watanabe Y, Mukai M, Kikuchi T, Ariga T, Nagashima T, Koh Z, Usui S, Odaka M, Sato H (1985) The study on the preoperative transcatheter arterial embolization for hepatocellular carcinoma. Jpn J Gastroenterol Surg 18:60–65
Nakao N, Kamino K, Miura K, Takayasu Y, Ohnishi M, Miura T (1992) Transcatheter arterial embolization in hepatocellular carcinoma: A long-term follow-up. Radiat Med 10:13–18
Nishimura Y, Uchida H, Guo Q, Matsuo N, Ohue S, Nishimine K, Sakaguchi H, Ohishi H, Yoshioka T, Fukui H, Tsujii T (1991) ranscatheter arterial embolization (TAB) for 1075 cases of hepatocellular carcinoma—Evaluation of TAE using lipiodol mixed with anticancer agents focusing on cumulative survival rate and 69 cases achieving 3-year survival. J Jpn Soc Cancer Ther 26:2279–2289
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Katsumori, T., Fujita, M., Takahashi, T. et al. Effective segmental chemoembolization of advanced hepatocellular carcinoma with tumor thrombus in the portal vein. Cardiovasc Intervent Radiol 18, 217–221 (1995). https://doi.org/10.1007/BF00239415
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DOI: https://doi.org/10.1007/BF00239415