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A horseradish peroxidase study of afferent connections of the globus pallidus in Macaca mulatta

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Summary

The high tonic discharge rates of globus pallidus neurons in awake monkeys suggest that these neurons may receive some potent excitatory input. Because most current electrophysiological evidence suggests that the major described pallidal afferent systems from the neostriatum are primarily inhibitory, we used retrograde transport of horseradish peroxidase (HRP) to identify possible additional sources of pallidal afferent fibers. The appropriate location was determined before HRP injection by mapping the characteristic high frequency discharge of single pallidal units in awake animals. In animals with injections confined to the internal pallidal segment, retrograde label was seen in neurons of the pedunculopontine nucleus, dorsal raphe nucleus, substantia nigra, caudate, putamen, subthalamic nucleus, parafascicular nucleus, zona incerta, medial and lateral subthalamic tegmentum, parabrachial nuclei, and locus coeruleus. An injection involving the external pallidal segment and the putamen as well resulted in additional labeling of cells in centromedian nucleus, pulvinar, and the ventromedial thalamus.

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Abbreviations

AC:

anterior commissure

CG:

central grey

CM:

centromedian nucleus

CN:

caudate nucleus

DM:

dorsomedial nucleus

DR:

dorsal raphe nucleus

DSCP:

decussation of superior cerebellar peduncle

GPe:

globus pallidus, external segment

GPi:

globus pallidus, internal segment

LC:

locus coeruleus

LL:

lateral lemniscus

MG:

medial geniculate nucleus

ML:

medial lemniscus

NVI:

abducens nucleus

OT:

optic tract

Pbl:

lateral parabrachial nucleus

Pbm:

medial parabrachial nucleus

Pf:

parafascicular nucleus

PPN:

pedunculopontine nucleus

PuO:

oral pulvinar nucleus

RN:

red nucleus

SCP:

superior cerebellar peduncle

SI:

substantia innominata

SNc:

substantia nigra, pars compacta

SNr:

substantia nigra, pars reticulata

STN:

subthalamic nucleus

TMT:

mamillothalamic tract

VA:

ventral anterior nucleus

VLc:

ventral lateral nucleus, pars caudalis

VLm:

ventral lateral nucleus, pars medialis

VLo:

ventral lateral nucleus, pars oralis

VPI:

ventral posterior inferior nucleus

VPM:

ventral posterior medial nucleus

VPLc:

ventral posterior lateral nucleus, pars caudalis

ZI:

zona incerta

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Authors and Affiliations

  1. Regional Primate Research Center and Departments of Neurological Surgery, Physiology and Biophysics, and Rehabilitation Medicine, University of Washington, 98195, Seattle, WA, USA

    J. L. DeVito Ph.D., M. E. Anderson & K. E. Walsh

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  1. J. L. DeVito Ph.D.
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  2. M. E. Anderson
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  3. K. E. Walsh
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DeVito, J.L., Anderson, M.E. & Walsh, K.E. A horseradish peroxidase study of afferent connections of the globus pallidus in Macaca mulatta. Exp Brain Res 38, 65–73 (1980). https://doi.org/10.1007/BF00237932

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  • DOI: https://doi.org/10.1007/BF00237932

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