Skip to main content
SpringerLink
Log in

Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections

  • Published:
Experimental Brain Research Aims and scope Submit manuscript

Summary

A quantitative electron microscopic study of synaptic terminal degeneration was performed in the supraoptic nucleus (NSO) after a variety of major transections or ablations, destroying or interrupting in different combinations the afferent pathways known from earlier and own light microscopic degeneration studies. Solutions of a set of equations, expressing the percentage degenerations in synaptic profiles after different combinations in which the several pathways are interrupted by the various interferences, enabled the authors to give the following percentage numbers for afferent synapses from different sources.

32.7% of supraoptic afferents originate from the brain stem probably representing the monoaminergic innervation of this nucleus. The medial basal hypothalamus (21.0%), amygdala (13.5%), septum (13.5%), hippocampus (8.5%) and olfactory tubercle and further rostral cortical region (17.0%) are the other main sites of origin of supraoptic nucleus afferents. There are no supraoptic afferents from the optic nerve, superior cervical ganglion or fimbria hippocampi.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

A:

nucleus accumbens

AB:

nucleus amygdaloideus basalis

AC:

nucleus amygdaloideus centralis

AL:

nucleus amygdaloideus lateralis

AM:

nucleus amygdaloideus medialis

ATV:

area tegmenti ventralis (Tsai)

C:

caudate-putamen

CA:

commissura anterior

CC:

corpus callosum

CFV:

commissura fornicvis ventralis

CO:

chiasma opticum

CP:

commissura posterior

D:

nucleus tractus diagnolis

DM:

nucleus dorsomedialis

DS:

decussationes supraoptica

F:

columna fornicis

FH:

fimbria hippocampi

FLM:

fasciculus longitudinalis medialis

FP:

fornix praecommissuralis

FS:

fornix superior

G:

globus pallidus

GD:

gyrus dentatus

HI:

hippocampus

IC:

capsula interna

IP:

nucleus interpeduncularis

LM:

lemniscus medialis

M:

medial forebrain bundle (MFB)

MM:

nucleus medialis thalami, pars medialis

NA:

nucleus arcuatus

R:

nucleus rhomboideus

RE:

nucleus reuniens

RV:

nucleus ruber

S:

stria medullaris thalami

SD:

nucleus dorsalis septi

SF:

nucleus fimbrialis septi

SG:

substantia grisea centralis

SL:

nucleus lateralis septi

SM:

nucleus medialis septi

SN:

substantia nigra

ST:

nucleus interstitialis striae terminalis

T:

tractus olfactorius lateralis

TD:

tractus diagonalis (Broca)

TO:

tractus opticus

TSTH:

tractus striohypothalamicus

TU:

tuberculum olfactorium

VM:

nucleus ventromedialis

References

  • Björklund, A., Nobin, A.: Fluorescence histochemical and microspectrofluorometric mapping of dopamine and noradrenaline cell groups in the rat diencephalon. Brain Res. 51, 193–205 (1973)

    Google Scholar 

  • Cowan, W.M., Guillery, R.W., Powell, T.P.S.: The origin of the mamillary peduncle and other hypothalamic connexions from the midbrain. J. Anat. (Lond.) 98, 345–363 (1964)

    Google Scholar 

  • Dahlström, A., Fuxe, K.: Existence of monoamine containing neurons in the cell bodies of brain stem neurons. Acta physiol. scand. 232, Suppl. 62, 1–53 (1964)

    Google Scholar 

  • De Olmos, J.S., Ingram, W.R.: The projection field of the stria terminalis in the rat brain. An experimental study. J. comp. Neurol. 146, 303–334 (1972)

    Google Scholar 

  • Fink, R.P., Heimer, L.: Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. Brain Res. 4, 369–375 (1967)

    Google Scholar 

  • Guillery, R.W.: Degeneration in the hypothalamic connexions of the albino rat. J. Anat. (Lond.) 91, 91–115 (1957)

    Google Scholar 

  • Gurdjian, E.S.: Olfactory connections in the albino rat, with special reference to the stria medullaris and the anterior commissure. J. comp. Neurol. 38, 127–163 (1925)

    Google Scholar 

  • Gurdjian, E.S.: The diencephalon of the albino rat. J. comp. Neurol. 43, 1–114 (1927)

    Google Scholar 

  • Halász, B., Pupp, L.: Hormone secretion of the anterior pituitary gland after physical interruption of all nervous pathways to the hypophysiotropic are. Endocrinology 77, 553–563 (1965)

    Google Scholar 

  • Hayward, J.N., Smith, W.K.: Influence of limbic system on neurohypophysis. Arch. Neurol. (Chic.) 9, 171–177 (1963)

    Google Scholar 

  • Heimer, L., Nauta, W.J.H.: The hypothalamic distribution of the stria terminalis in the rat. Brain Res. 13, 284–297 (1969)

    Google Scholar 

  • Johnson, T.N.: An experimental study of the fornix and hypothalamo-tegmental tracts in the cat. J. comp. Neurol. 125, 29–40 (1965)

    Google Scholar 

  • König, J.F.R., Klippel, R.A.: The Rat Brain: A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem. Baltimore: Williams and Wilkins 1963

    Google Scholar 

  • Krieg, J.: The hypothalamus of the albino rat. J. comp. Neurol. 55, 19–89 (1932)

    Google Scholar 

  • Leonard, C.M., Scott, J.W.: Origin and distribution of the amygdalofugal pathways in the rat: an experimental-neuroanatomical study. J. comp. Neurol. 141, 313–330 (1971)

    Google Scholar 

  • Leontovich, T.A.: The neurons of the magnocellular neurosecretory nuclei of the dog's hypothalamus. J. Hirnforsch. 11, 499–517 (1970)

    Google Scholar 

  • Léránth, Cs., Záborszky, L., Makara, G.B., Palkovits, M.: Degeneration von Synapsen im Nucleus supraoptious nach Unterbrechung der afferenten Systeme des Hypothalamus. Ergebn. Anat. Anz. 130, 587–593 (1972)

    Google Scholar 

  • Léránth, Cs., Záborszky, L., Marton, J., Palkovits, M.: Studies on the supraoptic nuclei in the rat. I. Synapses. Exp. Brain Res. 22, 509–523 (1975)

    Google Scholar 

  • Makara, G.B., Stark, E., Mészáros, T.: Corticotrophin release induced by E. coli endotoxin after removal of the medial hypothalamus. Endocrinology 88, 412–414 (1971)

    Google Scholar 

  • Makara, G.B., Stark, E., Marton, J., Mészáros, T.: Corticotrophin release induced by surgical trauma after transection of various afferent nervous pathways to the hypothalamus. J. Endocr. 53, 389–395 (1972)

    Google Scholar 

  • Mills, E., Wang, S.C.: Liberation of antidiuretic hormone: Location of ascending pathways. Amer. J. Physiol. 207, 1399–1404 (1964)

    Google Scholar 

  • Minderhoud, J.M.: Observations on the supra-optic decussations in the albino rat. J. comp. Neurol. 129, 297–312 (1967)

    Google Scholar 

  • Morest, D.K.: Connexions of the dorsal tegmental nucleus in rat and rabbit. J. Anat. (Lond.) 95, 229–246 (1961)

    Google Scholar 

  • Nauta, W.J.H.: An experimental study of the fornix in the rat. J. comp. Neurol. 104, 247–270 (1956)

    Google Scholar 

  • Nauta, W.J.H.: Hippocampal projections and related neural pathways to the midbrain in the rat. Brain 81, 319–341 (1958)

    Google Scholar 

  • Nauta, W.J.H.: Fibre degeneration following lesions of the amygdaloid complex in the monkey. J. Anat. (Lond.) 95, 515–531 (1961)

    Google Scholar 

  • Nauta, W.J.H., Kuypers, H.G.J.M.: Some ascending pathways in the brain stem reticular formation. In: Reticular Formation of the Brain, pp. 3–30. Ed. by Jasper, H.H. et al., Boston: Little, Brown and Company 1958

    Google Scholar 

  • Powell, T.P.S., Cowan, W.M., Raisman, G.: The central olfactory connections. J. Anat. (Lond.) 99, 791–813 (1965)

    Google Scholar 

  • Powell, E.W., Rorie, D.K.: Septal projections to nuclei functioning in oxytocin release. Amer. J. Anat. 120, 605–610 (1967)

    Google Scholar 

  • Raisman, G.: The connections of the septum. Brain 89, 317–348 (1966)

    Google Scholar 

  • Raisman, G., Cowan, W.M., Powell, T.P.S.: An experimental analysis of the efferent projection of the hippocampus. Brain 89, 83–108 (1966)

    Google Scholar 

  • Sachs, C., Jonsson, G., Fuxe, K.: Mapping of central noradrenaline pathways with 6-hydroxyDOPA. Brain Res. 63, 249–261 (1973)

    Google Scholar 

  • Szentágothai, J., Flerkó, B., Mess, B., Halász, B.: Hypothalamic Control of the Anterior Pituitary, p. 399. Budapest: Akadémiai Kiadó 1968

    Google Scholar 

  • Tangapregassom, A.M., Tangapregassom, M.I., Soulairac, A., Soulairac, M.L.: Effects des lésions septales sur l'ultrastructure du noyau supra-optique rat. Ann. Endocr. (Paris) 35, 149–152 (1974)

    Google Scholar 

  • Ungerstedt, U.: Stereotaxic mapping of monoamine pathways in the rat brain. Acta physiol. scand. 367, Suppl. 1–48 (1971)

    Google Scholar 

  • Woods, W.H., Holland, R.C., Powell, E.W.: Connections of cerebral structures functioning in neurohypophysial hormone release. Brain Res. 12, 26–46 (1969)

    Google Scholar 

  • Záborszky, L., Léránth, Cs., Palkovits, M.: Faserdegeneration im Hypothalamus und im limbischen System nach konventionellen (dorsomedialen) Penetrationen. Ergebn. Anat. Anz. 130, 595–600 (1972)

    Google Scholar 

  • Záborszky, L., Léránth, Cs., Marton, J., Palkovits, M.: Afferent brainstem pathways to hypothalamus and to limbic system in the rat. In: Hormones and Brain Function, pp. 449–457. Ed. by K. Lissák.s Budapest: Akadémiai Kiadó 1973

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 1st Department of Anatomy, Semmelweis University Medical School and Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

    L. Záborszky, Cs. Léránth, G. B. Makara & M. Palkovits

Authors
  1. L. Záborszky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cs. Léránth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. B. Makara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Palkovits
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Záborszky, L., Léránth, C., Makara, G.B. et al. Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections. Exp Brain Res 22, 525–540 (1975). https://doi.org/10.1007/BF00237352

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00237352

Key words

Search

Navigation