Summary
This paper deals with the ultrastructure of two types of intranuclear inclusions, “microfilamentous spindle-shaped” and “crystalloid”, present in paraventricular nucleus neurons of adult normal rats. These inclusions appear occasionally in some non-secretory neurons of the parvocellular system, but have never been seen in neurosecretory cells of the magnocellular system. The microfilamentous spindle-shaped inclusions show a close spatial relationship with the granulofibrillar body and interchromatin granules.
The distribution and functional significance of such structures are discussed in the light of recent ultrastructural and biochemical studies on nuclear inclusions.
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References
Barry, J.: Essai de classification, en technique de Golgi, des diverses catégories de neurones du noyau paraventriculaire chez la souris. Compt. Rend. Soc. Biol. (Paris) 169, 978–980 (1975)
Clattenburg, R.E., Singh, R.P., Montemurro, D.G.: Intranuclear filamentous inclusions in neurons of the rabbit hypothalamus. J. Ultrastruct. Res. 39, 549–555 (1972)
David, S., Nathaniel, E.J.H.: Intranuclear inclusions in the developing neurons of the rat cuneate nuclei. Cell Tissue Res. 193, 525–532 (1978)
Diepen, R.: Der Hypothalamus. In: Handbuch der mikroskopischen Anatomie des Menschen (Hrsg. W. Bargmann). Band IV/7, pp. 45–48. Göttingen, Heidelberg, Berlin: Springer 1962
Feldman, M.L., Peters, A.: Intranuclear rods and sheets in rat cochlear nucleus. J. Neurocytol. 1, 109–127 (1972)
Field, E.J., Peat, A.: Intranuclear inclusions in neurones and glia: a study in the ageing mouse. Gerontologia 17, 129–138 (1971)
Freund-Mercier, M.J., Richard, Ph., Miro, J.L.: Données functionnelles en faveur de l'existence de trois types de cellules dans le noyau paraventriculaire chez la ratte. Brain Res. 89, 149–154 (1975)
Fukui, Y.: Intranuclear actin bundles induced by dimethyl sulfoxide in interphase nucleus of Dictyostelium. J. Cell Biol. 76, 146–157 (1978)
Kim, S.U., Masurovsky, E.B., Benitez, H.H., Murray, M.R.: Histochemical studies of the intranuclear rodlet in neurons of chicken sympathetic and sensory ganglia. Histochemie 24, 33–40 (1970)
Lafarga, M., Palacios, G.: Intranuclear rodlets in retrochiasmatic area neurons of the hypothalamus of the rat. Experientia 33, 1368–1369 (1977)
Magalhaes, M.M.: Intranuclear bodies in cells of the rabbit and rat retina. Exp. Cell Res. 47, 628–632 (1967)
Masurovsky, E.B., Benitez, H.H., Kim, S.U., Murray, M.R.: Origin, development, and nature of intranuclear rodlets and associated bodies in chicken sympathetic neurons. J. Cell Biol. 44, 172–191 (1970)
Palay, S.L., Chan-Palay, V.: Cerebellar cortex. Berlin, Heidelberg, New York: Springer 1974
Pinching, A.J., Powell, T.P.S.: Ultrastructural features of transneuronal cell degeneration in the olfactory system. J. Cell Sci. 8, 253–287 (1971)
Popoff, N., Stewart, S.: The fine structure of nuclear inclusions in the brain of experimental golden hamsters. J. Ultrastruct. Res. 23, 347–361 (1968)
Seite, R., Escaig, J., Couineau, S.: Microfilaments et microtubules nucléaires et organisation ultrastructurale des bâtonnets intranucléaires des neurones sympathiques. J. Ultrastruct. Res. 37, 449–478 (1971a)
Seite, R., Mei, N., Couineau, S.: Modification quantitative des bâtonnets intranucléaires des neurones sympathiques sous l'influence de la stimulation électrique. Brain Res. 34, 277–290 (1971b)
Seite, R., Mei, N., Vuillet-Luciani, J.: Effect of electrical stimulation on nuclear microfilaments and microtubules of sympathetic neurons submitted to cycloheximide. Brain Res. 50, 419–423 (1973)
Seite, R., Leonetti, J., Vuillet-Luciani, J., Vio, M.: Cyclic AMP and ultrastructural organization of the nerve cell nucleus: stimulation of nuclear microtubules and microfilaments assembly in sympathetic neurons. Brain Res. 124, 41–51 (1977a)
Seite, R., Vuillet-Luciani, J., Vio, M., Cataldo, C.: Sur la présence d'inclusions nucléaires dans certains neurones du noyau caudé du rat: répartition, fréquence et organisation ultrastructurale. Biol. Cellulaire 30, 73–76 (1977b).
Siegesmund, K.A., Dutta, C.R., Fox, C.A.: The ultrastructure of the intranuclear rodlet in certain nerve cells. J. Anat. (London) 98, 93–97 (1964)
Sotelo, C., Palay, S.L.: The fine structure of the lateral vestibular nucleus in the rat. I. Neurons and neuroglial cells. J. Cell Biol. 36, 151–179 (1968)
Warchol, J.B.: Intranuclear microfilament bundles in the ependymal cells of the third ventricle of the rat. Cell Tissue Res. 194, 353–359 (1978)
Willey, T.J., Schultz, R.L.: Intranuclear inclusions in neurons of the cat primary olfactory system. Brain Res. 29, 31–45 (1971)
Zerbib, R., Vuillet-Luciani, J., Escaig, J., Seite, R.: Organisation tridimensionelle des “cristalloïdes” intranucléaires des neurones sympathiques, révélée par la platine goniométrique et l'étude de coupes sériées. J. Microsc. (Paris) 17, 111a (1973)
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Lafarga, M., Palacios, G. Nuclear inclusions in paraventricular nucleus neurons of the rat hypothalamus. Cell Tissue Res. 203, 223–229 (1979). https://doi.org/10.1007/BF00237236
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DOI: https://doi.org/10.1007/BF00237236