Summary
Adult male rats were injected with 6-hydroxydopamine, either into the lateral brain ventricle or directly into the dorsal hippocampus. They were adrenalectomized 5–7 days later, and following an additional 24 hours, the specific in vitro 3H- corticosterone binding capacity of dorsal hippocampal slices was determined by estimation of uptake of radioactivity by the nuclear fraction. Specific corticosterone binding was reduced by 40–50% in both experimental groups, as compared to vehicle-treated controls. These results suggest that the maintenance of normal dorsal hippocampal Corticosterone binding capacity is dependent upon the integrity of endogenous brain catecholaminergic neural systems.
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Partially supported by the Fund for Basic Research administered by the Israel Academy of Sciences and Humanities
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Weidenfeld, J., Siegel, R.A., Corcos, A.P. et al. Effect of 6-hydroxydopamine on in vitro hippocampal corticosterone binding capacity in the male rat. Exp Brain Res 52, 121–124 (1983). https://doi.org/10.1007/BF00237156
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DOI: https://doi.org/10.1007/BF00237156