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Molecular basis of epithelial Cl channels

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Conclusions

Until recently, the study of chloride channels largely has been neglected. Interest in physiological processes such as stabilization of resting membrane potential, volume and pH regulation, and transepithelial transport has provided the impetus for acquiring our present understanding of chloride channels. Molecular biological techniques have proven useful in increasing our understanding of epithelial chloride channels, at the very least by providing a structural basis for functional data. Knowledge of the structure of several families of chloride channels has provided us with the capability to probe functional questions via structural manipulations, and yielded answers essential to gaming a more complete perspective of the role of chloride channels in epithelia. It may be anticipated that a large number of new chloride channels, and maybe even new chloride channel families, will be cloned in the next few years. A major challenge will be to elucidate their functions in the cell, the epithelium, and the organism as a whole.

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We thank Claudius Lorenz and Blanche Schwappach for critical reading of the manuscript. Work in this laboratory is supported by the Deutsche Forschungsgemeinschaft, the United States Muscular Dystrophy Association, the International Human Frontiers in Science Program, and the Fonds der Chemischen Industrie.

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Fong, P., Jentsch, T.J. Molecular basis of epithelial Cl channels. J. Membarin Biol. 144, 189–197 (1995). https://doi.org/10.1007/BF00236832

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