Summary
cAMP concentrations in the preoptic region and cerebral cortex were studied in rats during exposure to low ambient temperature (−10 ° C) and after return to control ambient temperature (22 ° C).
Significant changes in cAMP concentration were found only in the preoptic region. On prolonged exposure to low ambient temperature the nucleotide concentration decreased and the circadian rhythm, observed in control conditions, disappeared. Return to control ambient temperature after exposure to low ambient temperature induced a steep increase and a long-lasting plateau in cAMP concentration. The results are discussed in terms of interaction between thermoregulatory and sleep-wakefulness processes.
Similar content being viewed by others
References
Altman PL, Dittmer DS (1966) Environmental biology, chapt I, Temperature. F.A.S.E.B., Bethesda, MA, pp 1–129
Bremer F (1973) Preoptic hypnogenic area and reticular activating system. Arch Ital Biol 111: 85–111
Daly J (1977) Cyclic nucleotides in the nervous system. Plenum Press, New York, pp 211–381
Hellon RF (1975) Monoamines, pyrogens and cations: Their action on control of body temperature. Pharmacol Rev 26: 289–321
Jouvet M (1972) The role of monoamines and acetylcholine containing neurons in the regulation of the sleep-waking cycle. Ergebn Physiol 64: 166–307
Kornbluth I, Siegel RA, Conforti N, Chowers I (1977) cAMP in temperature- and ADH-regulating centers after thermal stress. J Appl Physiol 42: 257–261
Lowry OH, Rosebrough NA, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275
Mao CC, Guidotti A, Costa E (1974) Interaction between γ-aminobutyric acid and guanosine cyclic 3′,5′-monophosphate in rat cerebellum. Mol Pharmacol 10: 736–745
Parmeggiani PL (1968) Telencephalo-diencephalic aspects of sleep mechanisms. Brain Res 7: 350–359
Parmeggiani PL (1977) Interaction between sleep and thermoregulation. Waking Sleep 1: 123–132
Parmeggiani PL, Rabini C (1970) Sleep and environmental temperature. Arch Ital Biol 108: 369–387
Schmidek WR, Hoshino K, Schmidek M, Timo-Iaria C (1972) Influence of environmental temperature on the sleep-wake-fulness cycle in the rat. Physiol Behav 8: 363–371
Sterman MB, Clemente CO (1962) Forebrain inhibitory mechanisms: Sleep patterns induced by basal forebrain stimulation in the behaving cat. Exp Neurol 6: 103–117
Toru M, Shibuya H, Shimazono Y (1976) Monoamine metabolism in rat brain after total sleep deprivation. In: Advances in sleep research, vol II Spectrum, New York, pp 116–130
Zamboni G, Perez E, Parmeggiani PL (1981) cAMP concentration in the hypothalamus and cerebral cortex of the rat in wakefulness and sleep. In: Sleep 1980. Karger, Basel, pp 331–333
Author information
Authors and Affiliations
Additional information
Supported by grant No. 79.01946.04 from the National Research Council (CNR), Rome, Italy
Rights and permissions
About this article
Cite this article
Perez, E., Zamboni, G. & Parmeggiani, P.L. cAMP concentration in the rat's preoptic region and cerebral cortex during sleep deprivation and recovery induced by ambient temperature. Exp Brain Res 47, 114–118 (1982). https://doi.org/10.1007/BF00235892
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00235892