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Effects of halothane on microtubules in the sciatic nerve of the rat

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Summary

The effect of halothane and colchicine on microtubule repolymerisation after exposure to cold has been examined in the sciatic nerve of the rat. Myelinated axons showed a significant decrease in microtubule numbers and density after exposure to both 20 mM halothane and 10−5 M colchicine; exposure to both agents simultaneously produced a further significant reduction when compared to halothane alone. It is suggested that halothane can interfere with microtubule repolymerisation in mammalian axons possibly in a similar way to that described in invertebrates.

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Authors and Affiliations

  1. Department of Pharmacology, Medical School, University Walk, BS8 1TD, Bristol, UK

    A. Livingston & G. A. Vergara

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  1. A. Livingston
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  2. G. A. Vergara
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Livingston, A., Vergara, G.A. Effects of halothane on microtubules in the sciatic nerve of the rat. Cell Tissue Res. 198, 137–144 (1979). https://doi.org/10.1007/BF00234841

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  • DOI: https://doi.org/10.1007/BF00234841

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