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Ontogeny and ultrastructure of somatostatin and calcitonin cells in the thyroid gland of the rat

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Summary

Calcitonin cells are relatively numerous in the thyroid gland of the rat. In contrast, somatostatin cells are very scarce except at the time of birth and a few days thereafter, when they are conspicuously numerous. Somatostatin cells of the thyroid gland, which are ultrastructurally similar to somatostatin cells in gut and pancreas, also contain immunoreactive calcitonin. It is not clear whether somatostatin cells in the rat thyroid gland produce calcitonin or accumulate calcitonin from the environment.

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References

  • Alumets J, Sundler F, Håkanson R (1977) Distribution, ontogeny and ultrastructure of somatostatin immunoreactive cells in the pancreas and gut. Cell Tissue Res 185:465–479

    Google Scholar 

  • Arimura A, Lundqvist G, Rothmann J, Chang R, Fernandez-Durango R, Elde R, Coy DH, Meyers C, Sehally AV (1978) Radioimmunoassay of somatostatin. Metabolism 27:Suppl 1:1139–1144

    Google Scholar 

  • Brownstein M, Arimura A, Sato H, Schally AV, Kizer JS (1975) The regional distribution of somatostatin in rat brain. Endocrinology 96:1456–1461

    Google Scholar 

  • Buffa R, Chayvialle JA, Fontana P, Usellini L, Capella C, Solcia E (1979) Parafollicular cells of rabbit thyroid store both calcitonin and somatostatin and resemble gut D cells ultrastructurally. Histochemistry 62:281–288

    Google Scholar 

  • Coons AH, Leduc EH, Connolly JM (1955) Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to the hyperimmune rabbit. J Exp Med 102:49–60

    Google Scholar 

  • Elde R, Hökfelt T, Johansson O, Schultzberg M, Efendic S, Luft R (1978) Cellular localization of somatostatin. Metabolism 27:Suppl. 1, 1151–1159

    Google Scholar 

  • Hökfelt T, Efendic S, Johansson O, Luft R, Arimura A (1975) Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special reference to the A1-cells of the pancreatic islets and to the hypothalamus. Acta Endocrinol 80:Suppl 200, 1–40

    Google Scholar 

  • Lundqvist G, Gustavsson S, Elde RP, Arimura A (1980) A radioimmunosorbent assay for plasma somatostatin. Clin Chim Acta. In press

  • Parsons JA, Erlandsen SL, Hegre OD, McEvoy RC, Elde RP (1976) Central and peripheral localization of somatostatin. Immunoenzyme immunocytochemical studies. J Histochem Cytochem 24:872–882

    Google Scholar 

  • Polak JM, Pearse AGE, Grimelius L, Bloom SR, Arimura A (1975) Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet 1:1220–1222

    Google Scholar 

  • Shapiro B, Berelowitz M, Pimstone BL, Kronheim S, Sheppard M (1979) Tissue and serum somatostatin-like immunoreactivity in fed, 15-h-fasted and 72-h-fasted rats. Diabetes 28:182–184

    Google Scholar 

  • Sternberger LA (1974) Immunocytochemistry. New Jersey, Prentice Hall Inc.

    Google Scholar 

  • Sundler F, Alumets J, Håkanson R, Björklund L, Ljungberg O (1977) Somatostatin-immunoreactive cells in medullary carcinoma of the thyroid. Am J Pathol 88:381–386

    Google Scholar 

  • Thorell J, Larson SM (1978a) Radioimmunoassay and related techniques. C V Mosby, St. Louis, Mo. p 200

    Google Scholar 

  • Thorell J, Larson SM (1978b) Radioimmunoassay and related techniques. C V Mosby, St. Louis, Mo. p 275

    Google Scholar 

  • Van Noorden S, Polak JM, Pearse AGE (1977) Single cellular origin of somatostatin and calcitonin in the rat thyroid gland. Histochemistry 53:243–247

    Google Scholar 

  • Yamada Y, Ito S, Matsubara Y, Kobayashi S (1977) Immunohistochemical demonstration of somatostatin-containing cells in the human, dog and rat thyroid. Tohoku J Exp Med 122:87–92

    Google Scholar 

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Alumets, J., Håkanson, R., Lundqvist, G. et al. Ontogeny and ultrastructure of somatostatin and calcitonin cells in the thyroid gland of the rat. Cell Tissue Res. 206, 193–201 (1980). https://doi.org/10.1007/BF00232763

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  • DOI: https://doi.org/10.1007/BF00232763

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