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A prostatic-like acid phosphatase is present in human lactating milk

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Summary

The presence of a prostatic-like acid phosphatase is reported in human lactating milk. Its activity is associated with skim milk and it could be separated from the other acid phosphatases only after Triton X-100 treatment. By all the criteria applied, it appears to be very similar to prostatic acid phosphatase. An approximate molecular weight of 96 000 was measured for the native enzyme, which is inhibited by L-(+)tartrate and has similar electrophoretic migration. Besides, it hydrolyzes choline-o-phosphate very well and cross-reacts with an antibody anti-prostatic acid phosphatase. This prostatic-like acid phosphatase has also been detected in a human mammary carcinoma from a lactating patient.

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Authors and Affiliations

  1. Department of Diagnostic Oncology, Hospital Mariano R. Castex, Balcarce 900, (1650), San Martin, Provincia de Buenos Aires, Argentina

    Osvaldo L. Podhajcer & Jorge E. Filmus

  2. Instituto de Investigaciones Bioquímicas ‘Fundación Campomar’,, Antonio Machado 151, (1405), Buenos Aires, Argentina

    Jose Mordoh

Authors
  1. Osvaldo L. Podhajcer
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  2. Jorge E. Filmus
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  3. Jose Mordoh
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Podhajcer, O.L., Filmus, J.E. & Mordoh, J. A prostatic-like acid phosphatase is present in human lactating milk. Mol Cell Biochem 66, 39–43 (1985). https://doi.org/10.1007/BF00231821

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  • DOI: https://doi.org/10.1007/BF00231821

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